eF-site ID 6iih-AB PDB Code 6iih Chain A, B click to enlarge Title crystal structure of mitochondrial calcium uptake 2(MICU2) Classification Calcium Binding Protein Compound Endolysin,Calcium uptake protein 2, mitochondrial Source (MICU2_HUMAN) Sequence A:  MNIFEMLRIDERLRLKIYKDTEGYYTIGIGHLLTKSPSLN AAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILR NAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRM LQQKRWDEAAVNLAKSIWYNQTPNRAKRVITTFRTGTWDA YHMLRKQRFMQFSSLEHEGEYYMTPRDFLFSVMFEQMTSV KKLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYL FLLTILTKPHSGFHVAFKMLDTDGNEMIEKREFFKLINTT LQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSK GLSFMRKEDFAEWLLFFTNTENKDIYWKNVREKLSAGESI SLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRA VKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKN RMHRGL B:  MNIFEMLRIDERLRLKIYKDTEGYYTIGIGHLLTKSPSLN AAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILR NAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRM LQQKRWDEAAVNLAKSIWYNQTPNRAKRVITTFRTGTWDA YHMLRKQRFMQFSSLEHEGEYYMTPRDFLFSVMFEQMEKK LTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFL LTILTKPHSGFHVAFKMLDTDGNEMIEKREFFKNTTLQMR FFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSKGLSF MRKEDFAEWLLFFTNTENKDIYWKNVREKLSAGESISLDE FKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVA TGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNR Description Functional site 1) chain A residue 264 type sequence D description binding site for residue CA A 501 source : AC1 2) chain A residue 266 type sequence D description binding site for residue CA A 501 source : AC1 3) chain A residue 268 type sequence N description binding site for residue CA A 501 source : AC1 4) chain A residue 270 type sequence M description binding site for residue CA A 501 source : AC1 5) chain A residue 275 type sequence E description binding site for residue CA A 501 source : AC1 6) chain B residue 264 type sequence D description binding site for residue CA B 501 source : AC2 7) chain B residue 266 type sequence D description binding site for residue CA B 501 source : AC2 8) chain B residue 268 type sequence N description binding site for residue CA B 501 source : AC2 9) chain B residue 270 type sequence M description binding site for residue CA B 501 source : AC2 10) chain B residue 272 type sequence E description binding site for residue CA B 501 source : AC2 11) chain B residue 275 type sequence E description binding site for residue CA B 501 source : AC2 12) chain B residue 454 type sequence D description binding site for residue CA B 502 source : AC3 13) chain B residue 456 type sequence D description binding site for residue CA B 502 source : AC3 14) chain B residue 458 type sequence D description binding site for residue CA B 502 source : AC3 15) chain B residue 460 type sequence C description binding site for residue CA B 502 source : AC3 16) chain B residue 465 type sequence E description binding site for residue CA B 502 source : AC3 17) chain A residue 117 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 18) chain A residue 132 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 19) chain B residue 117 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 20) chain B residue 132 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 11 type catalytic sequence E description 921 source MCSA : MCSA1 22) chain A residue 20 type catalytic sequence D description 921 source MCSA : MCSA1 23) chain B residue 11 type catalytic sequence E description 921 source MCSA : MCSA2 24) chain B residue 20 type catalytic sequence D description 921 source MCSA : MCSA2 25) chain A residue 11 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 11 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 20 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 20 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 32 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 104 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 32 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 104 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3

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