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Title
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Structure of RVFV Gn and human monoclonal antibody R12 |
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Classification
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STRUCTURAL PROTEIN/IMMUNE SYSTEM |
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Compound
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NSmGnGc |
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Source
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(6IEK) |
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Sequence
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A: |
EDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDV
LLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQS
AHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPP
KYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSK
LKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKK
VYLDKLDLKTEENLLPDSFVCFEHKELKSFDISQCPKIGG
HGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQV
SGVWKKPLCVGYERVVVKREL
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| B: |
QVQLVQSGAEVKKPGASVKVSCKVSGYTLTELSMHWVRQA
PGKGLEWMGGFDREDGETIYAQKFQGRVTMTEDTSTDTAY
MELSSLRSEDTAVYYCAIDPIRYNWNYGDYWGQGTLVTVS
SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV
SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ
TYICNVNHKPSNTKVDKKVEPKS
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| C: |
PVLTQPPSSSASPGESARLTCTLPSDISVSSYNIYWYQQK
PGSPPRFLLYYYSDSDKGQGSGVPSRFSGSKDASDNTGIL
LISGLQSEDEADYYCMIWPSNAWVFGGGTKLTVLGQPKAA
PSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADS
SPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYS
CQVTHEGSTVEKTVAPTE
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| D: |
EDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDV
LLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQS
AHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPP
KYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSK
LKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKK
VYLDKLDLKTEENLLPDSFVCFEHKELKSFDISQCPKIGG
HGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQV
SGVWKKPLCVGYERVVVKREL
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| E: |
QVQLVQSGAEVKKPGASVKVSCKVSGYTLTELSMHWVRQA
PGKGLEWMGGFDREDGETIYAQKFQGRVTMTEDTSTDTAY
MELSSLRSEDTAVYYCAIDPIRYNWNYGDYWGQGTLVTVS
SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV
SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ
TYICNVNHKPSNTKVDKKVEPKS
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| F: |
PVLTQPPSSSASPGESARLTCTLPSDISVSSYNIYWYQQK
PGSPPRFLLYYYSDSDKGQGSGVPSRFSGSKDASDNTGIL
LISGLQSEDEADYYCMIWPSNAWVFGGGTKLTVLGQPKAA
PSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADS
SPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYS
CQVTHEGSTVEKTVAPTE
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Description
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(1) |
NSmGnGc, Heavy chain of Fab R12, Light chain of Fab R12
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