eF-site ID 6idj-A PDB Code 6idj Chain A click to enlarge Title Crystal structure of human DHODH in complex with ferulenol Classification MEMBRANE PROTEIN Compound Dihydroorotate dehydrogenase (quinone), mitochondrial Source (PYRD_HUMAN) Sequence A:  MATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLP RARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLY KMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGF NSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSV DAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAE LRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIA SVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPL RDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAG ASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDA IGADHRR Description Functional site 1) chain A residue 245 type sequence R description binding site for residue SO4 A 401 source : AC1 2) chain A residue 248 type sequence H description binding site for residue SO4 A 401 source : AC1 3) chain A residue 307 type sequence K description binding site for residue ACT A 402 source : AC2 4) chain A residue 308 type sequence P description binding site for residue ACT A 402 source : AC2 5) chain A residue 311 type sequence D description binding site for residue ACT A 402 source : AC2 6) chain A residue 314 type sequence T description binding site for residue ACT A 402 source : AC2 7) chain A residue 315 type sequence Q description binding site for residue ACT A 402 source : AC2 8) chain A residue 318 type sequence R description binding site for residue ACT A 402 source : AC2 9) chain A residue 101 type sequence H description binding site for residue ACT A 403 source : AC3 10) chain A residue 150 type sequence N description binding site for residue ACT A 403 source : AC3 11) chain A residue 95 type sequence A description binding site for residue FMN A 404 source : AC4 12) chain A residue 96 type sequence A description binding site for residue FMN A 404 source : AC4 13) chain A residue 97 type sequence G description binding site for residue FMN A 404 source : AC4 14) chain A residue 100 type sequence K description binding site for residue FMN A 404 source : AC4 15) chain A residue 119 type sequence G description binding site for residue FMN A 404 source : AC4 16) chain A residue 120 type sequence S description binding site for residue FMN A 404 source : AC4 17) chain A residue 145 type sequence N description binding site for residue FMN A 404 source : AC4 18) chain A residue 147 type sequence Y description binding site for residue FMN A 404 source : AC4 19) chain A residue 181 type sequence N description binding site for residue FMN A 404 source : AC4 20) chain A residue 212 type sequence N description binding site for residue FMN A 404 source : AC4 21) chain A residue 255 type sequence K description binding site for residue FMN A 404 source : AC4 22) chain A residue 283 type sequence T description binding site for residue FMN A 404 source : AC4 23) chain A residue 284 type sequence N description binding site for residue FMN A 404 source : AC4 24) chain A residue 285 type sequence T description binding site for residue FMN A 404 source : AC4 25) chain A residue 305 type sequence S description binding site for residue FMN A 404 source : AC4 26) chain A residue 306 type sequence G description binding site for residue FMN A 404 source : AC4 27) chain A residue 309 type sequence L description binding site for residue FMN A 404 source : AC4 28) chain A residue 333 type sequence V description binding site for residue FMN A 404 source : AC4 29) chain A residue 334 type sequence G description binding site for residue FMN A 404 source : AC4 30) chain A residue 335 type sequence G description binding site for residue FMN A 404 source : AC4 31) chain A residue 355 type sequence L description binding site for residue FMN A 404 source : AC4 32) chain A residue 356 type sequence Y description binding site for residue FMN A 404 source : AC4 33) chain A residue 357 type sequence T description binding site for residue FMN A 404 source : AC4 34) chain A residue 100 type sequence K description binding site for residue ORO A 405 source : AC5 35) chain A residue 145 type sequence N description binding site for residue ORO A 405 source : AC5 36) chain A residue 147 type sequence Y description binding site for residue ORO A 405 source : AC5 37) chain A residue 148 type sequence G description binding site for residue ORO A 405 source : AC5 38) chain A residue 149 type sequence F description binding site for residue ORO A 405 source : AC5 39) chain A residue 212 type sequence N description binding site for residue ORO A 405 source : AC5 40) chain A residue 215 type sequence S description binding site for residue ORO A 405 source : AC5 41) chain A residue 217 type sequence N description binding site for residue ORO A 405 source : AC5 42) chain A residue 284 type sequence N description binding site for residue ORO A 405 source : AC5 43) chain A residue 285 type sequence T description binding site for residue ORO A 405 source : AC5 44) chain A residue 43 type sequence M description binding site for residue 9AU A 406 source : AC6 45) chain A residue 46 type sequence L description binding site for residue 9AU A 406 source : AC6 46) chain A residue 47 type sequence Q description binding site for residue 9AU A 406 source : AC6 47) chain A residue 52 type sequence P description binding site for residue 9AU A 406 source : AC6 48) chain A residue 55 type sequence A description binding site for residue 9AU A 406 source : AC6 49) chain A residue 56 type sequence H description binding site for residue 9AU A 406 source : AC6 50) chain A residue 59 type sequence A description binding site for residue 9AU A 406 source : AC6 51) chain A residue 63 type sequence T description binding site for residue 9AU A 406 source : AC6 52) chain A residue 68 type sequence L description binding site for residue 9AU A 406 source : AC6 53) chain A residue 134 type sequence V description binding site for residue 9AU A 406 source : AC6 54) chain A residue 136 type sequence R description binding site for residue 9AU A 406 source : AC6 55) chain A residue 356 type sequence Y description binding site for residue 9AU A 406 source : AC6 56) chain A residue 359 type sequence L description binding site for residue 9AU A 406 source : AC6 57) chain A residue 360 type sequence T description binding site for residue 9AU A 406 source : AC6 58) chain A residue 170 type sequence K description binding site for residue SO4 A 407 source : AC7 59) chain A residue 261 type sequence T description binding site for residue SO4 A 407 source : AC7 60) chain A residue 263 type sequence Q description binding site for residue SO4 A 407 source : AC7 61) chain A residue 246 type sequence R description binding site for residue SO4 A 408 source : AC8 62) chain A residue 249 type sequence R description binding site for residue SO4 A 408 source : AC8 63) chain A residue 168 type sequence Q description binding site for residue ACT A 409 source : AC9 64) chain A residue 169 type sequence A description binding site for residue ACT A 409 source : AC9 65) chain A residue 172 type sequence T description binding site for residue ACT A 409 source : AC9 66) chain A residue 205 type sequence L description binding site for residue ACT A 409 source : AC9 67) chain A residue 207 type sequence D description binding site for residue ACT A 409 source : AC9 68) chain A residue 114-133 type prosite sequence GFVEIGSVTPKPQEGNPRPR description DHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GfveiGSVTpkpQeGNprPR source prosite : PS00911 69) chain A residue 330-350 type prosite sequence IIGVGGVSSGQDALEKIRAGA description DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIGvGGVsSgqdAleKIrAGA source prosite : PS00912 70) chain A residue 145 type catalytic sequence N description 109 source MCSA : MCSA1 71) chain A residue 149 type catalytic sequence F description 109 source MCSA : MCSA1 72) chain A residue 215 type catalytic sequence S description 109 source MCSA : MCSA1 73) chain A residue 217 type catalytic sequence N description 109 source MCSA : MCSA1 74) chain A residue 218 type catalytic sequence T description 109 source MCSA : MCSA1 75) chain A residue 255 type catalytic sequence K description 109 source MCSA : MCSA1 76) chain A residue 284 type catalytic sequence N description 109 source MCSA : MCSA1 77) chain A residue 120 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 78) chain A residue 181 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 79) chain A residue 212 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 80) chain A residue 255 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 81) chain A residue 283 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 82) chain A residue 306 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 83) chain A residue 335 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 84) chain A residue 356 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 85) chain A residue 96 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 86) chain A residue 145 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI4 87) chain A residue 284 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI4 88) chain A residue 100 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI4 89) chain A residue 32-396 type TOPO_DOM sequence TGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRA RFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKM GFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNS HGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDA AEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELR RLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASV VKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRD LSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGAS LVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIG ADHRR description Mitochondrial intermembrane => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 90) chain A residue 215 type ACT_SITE sequence S description Nucleophile source Swiss-Prot : SWS_FT_FI2

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