eF-site ID 6i8t-A PDB Code 6i8t Chain A click to enlarge Title THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH AN ISOINDOLINONE INHIBITOR Classification TRANSFERASE Compound Poly [ADP-ribose] polymerase 1 Source (PARP1_CHICK) Sequence A:  KSKLAKPIQDLIKMIFDVESMKKAMVEFEIDLQKMPLGKL SKRQIQSAYSILNEVQQAVSDGGSESQILDLSNRFYTLIP HDFGMKKPPLLSNLEYIQAKVQMLDNLLDIEVAYSLLRGG NEDGDKDPIDINYEKLRTDIKVVDKDSEEAKIIKQYVKNT HAATHNAYDLKVVEIFRIEREGESQRYKPFKQLHNRQLLW HGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMV SKSANYCHTSQADPIGLILLGEVALGNMYELKNASHITKL PKGKHSVKGLGKTAPDPTATTTLDGVEVPLGNGISTGIND TCLLYNEYIVYDVAQVNLKYLLKLKFNY Description (1)  Poly [ADP-ribose] polymerase 1 (E.C.2.4.2.30) Functional site 1) chain A residue 763 type sequence Q description binding site for residue H7Z A 1101 source : AC1 2) chain A residue 862 type sequence H description binding site for residue H7Z A 1101 source : AC1 3) chain A residue 863 type sequence G description binding site for residue H7Z A 1101 source : AC1 4) chain A residue 888 type sequence G description binding site for residue H7Z A 1101 source : AC1 5) chain A residue 896 type sequence Y description binding site for residue H7Z A 1101 source : AC1 6) chain A residue 897 type sequence F description binding site for residue H7Z A 1101 source : AC1 7) chain A residue 904 type sequence S description binding site for residue H7Z A 1101 source : AC1 8) chain A residue 907 type sequence Y description binding site for residue H7Z A 1101 source : AC1 9) chain A residue 904 type catalytic sequence S description 76 source MCSA : MCSA1 10) chain A residue 907 type catalytic sequence Y description 76 source MCSA : MCSA1 11) chain A residue 988 type catalytic sequence E description 76 source MCSA : MCSA1 12) chain A residue 988 type ACT_SITE sequence E description For poly [ADP-ribose] polymerase activity => ECO:0000250|UniProtKB:P09874 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 862 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 871 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 878 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 904 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2

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