eF-site ID 6i8s-ABCDEFGHIJKL PDB Code 6i8s Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 Classification BLOOD CLOTTING Compound Plasminogen activator inhibitor 1 Source (6I8S) Sequence A:  SYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAM LQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGP WNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVD FSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVL VNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQT NKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEV PLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVD LRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVK IEVNESGTARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQV MEP B:  SYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAM LQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGP WNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVD FSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVL VNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQT NKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEV PLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVD LRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVK IEVNESGTARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQV MEP C:  SYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAM LQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGP WNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVD FSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVL VNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQT NKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEV PLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVD LRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVK IEVNESGTARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQV MEP D:  SYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAM LQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGP WNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVD FSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVL VNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQT NKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEV PLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVD LRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVK IEVNESGTARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQV MEP E:  QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQA PGQGLEWMGGIIPTFGTANYAQKFQGRVTITADESTSTAY MELSSLRSEDTAVYYCARERRQWLEGHFDYWGRGTLVTVS SASTKGPSVFPLAPTAALGCLVKDYFPQPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKKVEPK F:  QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQA PGQGLEWMGGIIPTFGTANYAQKFQGRVTITADESTSTAY MELSSLRSEDTAVYYCARERRQWLEGHFDYWGRGTLVTVS SASTKGPSVFPLAPTAALGCLVKDYFPQPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKKVEPK G:  QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQA PGQGLEWMGGIIPTFGTANYAQKFQGRVTITADESTSTAY MELSSLRSEDTAVYYCARERRQWLEGHFDYWGRGTLVTVS SASTKGPSVFPLAPTAALGCLVKDYFPQPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKKVEPK H:  QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQA PGQGLEWMGGIIPTFGTANYAQKFQGRVTITADESTSTAY MELSSLRSEDTAVYYCARERRQWLEGHFDYWGRGTLVTVS SASTKGPSVFPLAPTAALGCLVKDYFPQPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKKVEPK I:  DIQMTQSPSTLSASVGDRVTITCRASEGIYHNLAWYQQKP GKAPKLLIYKASSLASGVPSRFSGSRSGTEFTLTISSLQP DDFATYYCQQYSNYPLTFGGGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNR J:  DIQMTQSPSTLSASVGDRVTITCRASEGIYHNLAWYQQKP GKAPKLLIYKASSLASGVPSRFSGSRSGTEFTLTISSLQP DDFATYYCQQYSNYPLTFGGGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNR K:  DIQMTQSPSTLSASVGDRVTITCRASEGIYHNLAWYQQKP GKAPKLLIYKASSLASGVPSRFSGSRSGTEFTLTISSLQP DDFATYYCQQYSNYPLTFGGGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNR L:  DIQMTQSPSTLSASVGDRVTITCRASEGIYHNLAWYQQKP GKAPKLLIYKASSLASGVPSRFSGSRSGTEFTLTISSLQP DDFATYYCQQYSNYPLTFGGGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNR Description Functional site 1) chain A residue 329 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 2) chain B residue 329 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 3) chain C residue 329 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 4) chain D residue 329 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 5) chain A residue 352-362 type prosite sequence IIIDRPFLFVV description SERPIN Serpins signature. IIIDRPFLFvV source prosite : PS00284 6) chain I residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 7) chain E residue 202-208 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 8) chain A residue 346 type SITE sequence R description Reactive bond source Swiss-Prot : SWS_FT_FI1 9) chain B residue 346 type SITE sequence R description Reactive bond source Swiss-Prot : SWS_FT_FI1 10) chain C residue 346 type SITE sequence R description Reactive bond source Swiss-Prot : SWS_FT_FI1 11) chain D residue 346 type SITE sequence R description Reactive bond source Swiss-Prot : SWS_FT_FI1 12) chain A residue 209 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI2 13) chain A residue 265 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI2 14) chain B residue 209 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI2 15) chain B residue 265 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI2 16) chain C residue 209 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI2 17) chain C residue 265 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI2 18) chain D residue 209 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI2 19) chain D residue 265 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI2

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