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eF-site ID
|
6i8s-A |
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PDB Code
|
6i8s |
|
Chain
|
A |
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click to enlarge
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Title
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Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 |
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Classification
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BLOOD CLOTTING |
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Compound
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Plasminogen activator inhibitor 1 |
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Source
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(6I8S) |
|
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Sequence
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A: |
SYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAM
LQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGP
WNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVD
FSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVL
VNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQT
NKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEV
PLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVD
LRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVK
IEVNESGTARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQV
MEP
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Description
|
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Functional site
|
|
|
1)
|
chain |
A |
| residue |
209 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
A |
| residue |
265 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
346 |
| type |
SITE |
| sequence |
R
|
| description |
Reactive bond
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
329 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
A |
| residue |
352-362 |
| type |
prosite |
| sequence |
IIIDRPFLFVV
|
| description |
SERPIN Serpins signature. IIIDRPFLFvV
|
| source |
prosite : PS00284
|
|
|
|