eF-site ID 6i7t-ABCDEFGHIJKLMNOP PDB Code 6i7t Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P Title eIF2B:eIF2 complex Classification TRANSLATION Compound Translation initiation factor eIF-2B subunit alpha Source (IF2G_YEAST) Sequence A:  MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPE TAAEMINTIKSSTEELIKSIPNSVSLRAGCDIFMRFVLRN LHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFI ADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSK QGNQLYTLLEQKGIPVTLIVDSAVGAVIDKVDKVFVGAEG VAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMF PLSSDDLPMAGPPLDFTRRTDDLEDALRGPTIDYTAQEYI TALITDLGVLTPSAVSEELIKMWYD B:  MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPE TAAEMINTIKSSTEELIKSIPNSVSLRAGCDIFMRFVLRN LHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFI ADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSK QGNQLYTLLEQKGIPVTLIVDSAVGAVIDKVDKVFVGAEG VAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMF PLSSDDLPMAGPPLDFTRRTDDLEDALRGPTIDYTAQEYI TALITDLGVLTPSAVSEELIKMWYD C:  LEQSFDNSSLISSVKELLLNKDLIHPSILLLTSHLAHYKI VGSIPRCIAMLEVFQIVIKDYQTPKGTTLSRNLTSYLSHQ IDLLKKARPLSVTMGNAIRWLKQEISLIDPSTPDKAAKKD LCEKIGQFAKEKIELADQLIIDNASTQIEESTTIVTYGSS KVLTELLLHNAISLKKNIKVIVVDSRPLFEGRKMAETLRN AGVNVMYALITSLDTIFNMDVDYVFLGAHSILSNGFLYSR AGTAMLAMSAKRRNIPVLVCCESLKFSQRVQLDSVTFNEL ADPNDLVNKNILDGWQELPSLNIVNILYDLTPPEYIKKVI TEFGALPPSSVPVILREYKGSA D:  LEQSFDNSSLISSVKELLLNKDLIHPSILLLTSHLAHYKI VGSIPRCIAMLEVFQIVIKDYQTPKGTTLSRNLTSYLSHQ IDLLKKARPLSVTMGNAIRWLKQEISLIDPSTPDKAAKKD LCEKIGQFAKEKIELADQLIIDNASTQIEESTTIVTYGSS KVLTELLLHNAISLKKNIKVIVVDSRPLFEGRKMAETLRN AGVNVMYALITSLDTIFNMDVDYVFLGAHSILSNGFLYSR AGTAMLAMSAKRRNIPVLVCCESLKFSQRVQLDSVTFNEL ADPNDLVNKNILDGWQELPSLNIVNILYDLTPPEYIKKVI TEFGALPPSSVPVILREYKGSA E:  SDVNVTIDTFVAKLKRRQVQGSYAIALETLQLLMRFISAA RWNHVNDLIEQIRDLGNSLEKAHPTAFSCGNVIRRILAVL RDEVEEDTMSTTVTSTSVAEPLISSMFNLLQKPESSMKTK TDYRQVAIQGIKDLIDEIKNIDEGIQQIAIDLIHDHEILL TPTPDSKTVLKFLITARERSNRTFTVLVTEGFPNNTKNAH EFAKKLAQHNIETLVVPDSAVFALMSRVGKVIIGTKAVFV NGGTISSNSGVSSVCECAREFRTPVFAVAGLYKLSPLYPF DVEKFVEFGGSQRILPRMDPRKRLDTVNQITDYVPPENID IYITNVGGFNPSFIYRIAWDNYKQIDVHLDKNKA F:  SDVNVTIDTFVAKLKRRQVQGSYAIALETLQLLMRFISAA RWNHVNDLIEQIRDLGNSLEKAHPTAFSCGNVIRRILAVL RDEVEEDTMSTTVTSTSVAEPLISSMFNLLQKPESSMKTK TDYRQVAIQGIKDLIDEIKNIDEGIQQIAIDLIHDHEILL TPTPDSKTVLKFLITARERSNRTFTVLVTEGFPNNTKNAH EFAKKLAQHNIETLVVPDSAVFALMSRVGKVIIGTKAVFV NGGTISSNSGVSSVCECAREFRTPVFAVAGLYKLSPLYPF DVEKFVEFGGSQRILPRMDPRKRLDTVNQITDYVPPENID IYITNVGGFNPSFIYRIAWDNYKQIDVHLDKNKA G:  EDRLQAVVLTDSYETRFMPLTAVKPRCLLPLANVPLIEYT LEFLAKAGVHEVFLICSSHANQINDYIENSKWNLPWSPFK ITTIMSPEARCTGDVMRDLDNRGIITGDFILVSGDVLTNI DFSKMLEFHKKMHLQDKDHISTMCLSKASTYPKTRTIEPA AFVLDKSTSRCIYYQDLPLPSSREKTSIQIDPELLDNVDE FVIRNDLIDCRIDICTSHVPLIFQENFDYQSLRTDFVKGV ISSDILGKHIYAYLTDEYAVRVESWQTYDTISQDFLGRWC YPLVLDSNIQDDQTYSYESRHIYKEKDVVLAQSCKIGKCT AIGSGTKIGEGTKIENSVIGRNCQIGENIRIKNSFIWDDC IIGNNSIIDHSLIASNATLGSNVRLNDGCIIGFNVKIDDN MDLDRNTKIS H:  EDRLQAVVLTDSYETRFMPLTAVKPRCLLPLANVPLIEYT LEFLAKAGVHEVFLICSSHANQINDYIENSKWNLPWSPFK ITTIMSPEARCTGDVMRDLDNRGIITGDFILVSGDVLTNI DFSKMLEFHKKMHLQDKDHISTMCLSKASTYPKTRTIEPA AFVLDKSTSRCIYYQDLPLPSSREKTSIQIDPELLDNVDE FVIRNDLIDCRIDICTSHVPLIFQENFDYQSLRTDFVKGV ISSDILGKHIYAYLTDEYAVRVESWQTYDTISQDFLGRWC YPLVLDSNIQDDQTYSYESRHIYKEKDVVLAQSCKIGKCT AIGSGTKIGEGTKIENSVIGRNCQIGENIRIKNSFIWDDC IIGNNSIIDHSLIASNATLGSNVRLNDGCIIGFNVKIDDN MDLDRNTKIS I:  SIQAFVFCGALLPIGNRPMIEYVLDWCDQADGLTSFLSLR KQQFELIYKALSNSNHSHHLQDPKKINFIPSKANSTGESL QKELLPRINGDFVILPCDFVTDIPPQVLVDQFRNRDDNNL AMTIYYKNSLDSSIDKKQQQKQKQQQFFTVYSENEDSERQ PILLDVYSQRDVTKTKYLQIRSHLLWNYPNLTVSTKLLNS FIYFCSFELCQLLKLGPQSMSRQASFKDPFTGNQGIFILP NETLFIRANNLNAYMDANRFVLKIKSQT J:  SIQAFVFCGALLPIGNRPMIEYVLDWCDQADGLTSFLSLR KQQFELIYKALSNSNHSHHLQDPKKINFIPSKANSTGESL QKELLPRINGDFVILPCDFVTDIPPQVLVDQFRNRDDNNL AMTIYYKNSLDSSIDKKQQQKQKQQQFFTVYSENEDSERQ PILLDVYSQRDVTKTKYLQIRSHLLWNYPNLTVSTKLLNS FIYFCSFELCQLLKLGPQSMSRQASFKDPFTGNQGIFILP NETLFIRANNLNAYMDANRFVLKIKSQT K:  TSHCRFYENKYPEIDDIVMVNVQQIAEMGAYVKLLEYDNI EGMILLSELSRRRIRSIQKLIRVGKNDVAVVLRVDKEKGY IDLSKRRVSSEDIIKCEEKYQKSKTVHSILRYCAEKFQIP LEELYKTIAWPLSRKFGHAYEAFKLSIIDETVWEGIEPPS KDVLDELKNYISVKIRADVEVSCFSYEGIDAIKDALKSAE DVKVKLVAAPLYVLTTQALDKQKGIEQLESAIEKITEVIT KYGGVCNIT L:  TSHCRFYENKYPEIDDIVMVNVQQIAEMGAYVKLLEYDNI EGMILLSELSRRRIRSIQKLIRVGKNDVAVVLRVDKEKGY IDLSKRRVSSEDIIKCEEKYQKSKTVHSILRYCAEKFQIP LEELYKTIAWPLSRKFGHAYEAFKLSIIDETVWEGIEPPS KDVLDELKNYISVKIRADVEVSCFSYEGIDAIKDALKSAE DVKVKLVAAPLYVLTTQALDKQKGIEQLESAIEKITEVIT KYGGVCNIT M:  VGLPYSELLSRFFNILR N:  VGLPYSELLSRFFNILR O:  QATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNIT IKLGYANAKIYKCQEEISPKCQRPGCPGRYKLVRHVSFVD CPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHL AAIEIMKLKHVIILQNKVDLMREESALEHQKSILKFIRGT IADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISP RLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEI EIRPGIVTIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVG TKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRR LLGVKKQAKVRKLEPNEVLMVNIGSTATGARVVAVKADMA RLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKK P:  QATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNIT IKLGYANAKIYKCQEEISPKCQRPGCPGRYKLVRHVSFVD CPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHL AAIEIMKLKHVIILQNKVDLMREESALEHQKSILKFIRGT IADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISP RLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEI EIRPGIVTIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVG TKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRR LLGVKKQAKVRKLEPNEVLMVNIGSTATGARVVAVKADMA RLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKK Description Functional site 1) chain O residue 110 type BINDING sequence A description BINDING => ECO:0000269|PubMed:30475211 source Swiss-Prot : SWS_FT_FI1 2) chain O residue 249 type BINDING sequence N description BINDING => ECO:0000269|PubMed:30475211 source Swiss-Prot : SWS_FT_FI1 3) chain O residue 284 type BINDING sequence S description BINDING => ECO:0000269|PubMed:30475211 source Swiss-Prot : SWS_FT_FI1 4) chain P residue 110 type BINDING sequence A description BINDING => ECO:0000269|PubMed:30475211 source Swiss-Prot : SWS_FT_FI1 5) chain P residue 249 type BINDING sequence N description BINDING => ECO:0000269|PubMed:30475211 source Swiss-Prot : SWS_FT_FI1 6) chain P residue 284 type BINDING sequence S description BINDING => ECO:0000269|PubMed:30475211 source Swiss-Prot : SWS_FT_FI1 7) chain O residue 258 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI3 8) chain P residue 258 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI3

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