eF-site ID 6i5i-A
PDB Code 6i5i
Chain A

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Title Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound 12h
Classification TRANSFERASE
Compound Dual specificity protein kinase CLK1
Source (CLK1_HUMAN)
Sequence A:  SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGG
RHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCV
QMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHI
RKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAY
NPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHY
RAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSK
EHLAMMERILGPLPKHMIQKTRKRKYFRLDWDEHSSAGRY
VSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITL
REALKHPFFDLLKKS
Description


Functional site

1) chain A
residue 167
type
sequence L
description binding site for residue H3E A 501
source : AC1

2) chain A
residue 172
type
sequence F
description binding site for residue H3E A 501
source : AC1

3) chain A
residue 189
type
sequence A
description binding site for residue H3E A 501
source : AC1

4) chain A
residue 191
type
sequence K
description binding site for residue H3E A 501
source : AC1

5) chain A
residue 241
type
sequence F
description binding site for residue H3E A 501
source : AC1

6) chain A
residue 242
type
sequence E
description binding site for residue H3E A 501
source : AC1

7) chain A
residue 244
type
sequence L
description binding site for residue H3E A 501
source : AC1

8) chain A
residue 245
type
sequence G
description binding site for residue H3E A 501
source : AC1

9) chain A
residue 292
type
sequence E
description binding site for residue H3E A 501
source : AC1

10) chain A
residue 295
type
sequence L
description binding site for residue H3E A 501
source : AC1

11) chain A
residue 233
type
sequence H
description binding site for residue EDO A 502
source : AC2

12) chain A
residue 234
type
sequence H
description binding site for residue EDO A 502
source : AC2

13) chain A
residue 220
type
sequence S
description binding site for residue EDO A 503
source : AC3

14) chain A
residue 322
type
sequence K
description binding site for residue EDO A 503
source : AC3

15) chain A
residue 160
type
sequence R
description binding site for residue EDO A 504
source : AC4

16) chain A
residue 243
type
sequence L
description binding site for residue EDO A 505
source : AC5

17) chain A
residue 244
type
sequence L
description binding site for residue EDO A 505
source : AC5

18) chain A
residue 297
type
sequence V
description binding site for residue EDO A 505
source : AC5

19) chain A
residue 298
type
sequence Q
description binding site for residue EDO A 505
source : AC5

20) chain A
residue 299
type
sequence S
description binding site for residue EDO A 505
source : AC5

21) chain A
residue 244
type
sequence L
description binding site for residue EDO A 506
source : AC6

22) chain A
residue 245
type
sequence G
description binding site for residue EDO A 506
source : AC6

23) chain A
residue 246
type
sequence L
description binding site for residue EDO A 506
source : AC6

24) chain A
residue 252
type
sequence I
description binding site for residue EDO A 507
source : AC7

25) chain A
residue 255
type
sequence N
description binding site for residue EDO A 507
source : AC7

26) chain A
residue 258
type
sequence L
description binding site for residue EDO A 507
source : AC7

27) chain A
residue 259
type
sequence P
description binding site for residue EDO A 507
source : AC7

28) chain A
residue 260
type
sequence F
description binding site for residue EDO A 507
source : AC7

29) chain A
residue 259
type
sequence P
description binding site for residue EDO A 508
source : AC8

30) chain A
residue 260
type
sequence F
description binding site for residue EDO A 508
source : AC8

31) chain A
residue 261
type
sequence R
description binding site for residue EDO A 508
source : AC8

32) chain A
residue 262
type
sequence L
description binding site for residue EDO A 508
source : AC8

33) chain A
residue 373
type
sequence Y
description binding site for residue EDO A 508
source : AC8

34) chain A
residue 441
type
sequence L
description binding site for residue EDO A 508
source : AC8

35) chain A
residue 259
type
sequence P
description binding site for residue EDO A 509
source : AC9

36) chain A
residue 262
type
sequence L
description binding site for residue EDO A 510
source : AD1

37) chain A
residue 263
type
sequence D
description binding site for residue EDO A 510
source : AD1

38) chain A
residue 266
type
sequence R
description binding site for residue EDO A 510
source : AD1

39) chain A
residue 446
type
sequence E
description binding site for residue EDO A 510
source : AD1

40) chain A
residue 440
type
sequence M
description binding site for residue EDO A 511
source : AD2

41) chain A
residue 441
type
sequence L
description binding site for residue EDO A 511
source : AD2

42) chain A
residue 442
type
sequence S
description binding site for residue EDO A 511
source : AD2

43) chain A
residue 443
type
sequence Q
description binding site for residue EDO A 511
source : AD2

44) chain A
residue 419
type
sequence W
description binding site for residue EDO A 512
source : AD3

45) chain A
residue 420
type
sequence D
description binding site for residue EDO A 512
source : AD3

46) chain A
residue 423
type
sequence S
description binding site for residue EDO A 512
source : AD3

47) chain A
residue 200
type
sequence C
description binding site for residue EDO A 513
source : AD4

48) chain A
residue 201
type
sequence E
description binding site for residue EDO A 513
source : AD4

49) chain A
residue 204
type
sequence R
description binding site for residue EDO A 513
source : AD4

50) chain A
residue 385
type
sequence K
description binding site for residue EDO A 513
source : AD4

51) chain A
residue 410
type
sequence K
description binding site for residue EDO A 513
source : AD4

52) chain A
residue 411
type
sequence Y
description binding site for residue EDO A 513
source : AD4

53) chain A
residue 288
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

54) chain A
residue 167
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

55) chain A
residue 191
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

56) chain A
residue 167-191
type prosite
sequence LGEGAFGKVVECIDHKAGGRHVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVVeCidhkaggrh.........VAVK
source prosite : PS00107

57) chain A
residue 284-296
type prosite
sequence LTHTDLKPENILF
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LtHtDLKpeNILF
source prosite : PS00108


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