eF-site ID 6hwt-A PDB Code 6hwt Chain A click to enlarge Title Crystal structure of p38alpha in complex with a reduced photoswitchable 2-Azothiazol-based Inhibitor (compound 31) Classification TRANSFERASE Compound Mitogen-activated protein kinase 14 Source (MK14_HUMAN) Sequence A:  RPTFYRQELNKTIWEVPERYQNLSPVGSAYGSVCAAFDTK TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG LLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELK ILDFGLARTRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL LTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR ITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDE WKSLTYDEVISFVPPP Description Functional site 1) chain A residue 30-54 type prosite sequence VGSAYGSVCAAFDTKTGLRVAVKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK source prosite : PS00107 2) chain A residue 59-162 type prosite sequence FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE FNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL KYIHSADIIHRDLKPSNLAVNEDC description MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC source prosite : PS01351 3) chain A residue 168 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 4) chain A residue 30 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 5) chain A residue 53 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 6) chain A residue 16 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18691976 source Swiss-Prot : SWS_FT_FI4 7) chain A residue 53 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21444723 source Swiss-Prot : SWS_FT_FI5 8) chain A residue 152 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21444723 source Swiss-Prot : SWS_FT_FI5 9) chain A residue 263 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:17525332 source Swiss-Prot : SWS_FT_FI8 10) chain A residue 323 type MOD_RES sequence Y description Phosphotyrosine; by ZAP70 => ECO:0000269|PubMed:15735648 source Swiss-Prot : SWS_FT_FI9

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