eF-site ID 6hwt-A
PDB Code 6hwt
Chain A

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Title Crystal structure of p38alpha in complex with a reduced photoswitchable 2-Azothiazol-based Inhibitor (compound 31)
Classification TRANSFERASE
Compound Mitogen-activated protein kinase 14
Source (MK14_HUMAN)
Sequence A:  RPTFYRQELNKTIWEVPERYQNLSPVGSAYGSVCAAFDTK
TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG
LLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD
HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELK
ILDFGLARTRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL
LTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR
NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR
ITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDE
WKSLTYDEVISFVPPP
Description


Functional site

1) chain A
residue 30-54
type prosite
sequence VGSAYGSVCAAFDTKTGLRVAVKK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK
source prosite : PS00107

2) chain A
residue 59-162
type prosite
sequence FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE
FNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL
KYIHSADIIHRDLKPSNLAVNEDC
description MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC
source prosite : PS01351

3) chain A
residue 168
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 30
type BINDING
sequence V
description
source Swiss-Prot : SWS_FT_FI2

5) chain A
residue 53
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI2

6) chain A
residue 16
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:18691976
source Swiss-Prot : SWS_FT_FI4

7) chain A
residue 53
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:21444723
source Swiss-Prot : SWS_FT_FI5

8) chain A
residue 152
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:21444723
source Swiss-Prot : SWS_FT_FI5

9) chain A
residue 263
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:17525332
source Swiss-Prot : SWS_FT_FI8

10) chain A
residue 323
type MOD_RES
sequence Y
description Phosphotyrosine; by ZAP70 => ECO:0000269|PubMed:15735648
source Swiss-Prot : SWS_FT_FI9


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