eF-site ID 6hwo-D PDB Code 6hwo Chain D click to enlarge Title Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335 Classification HYDROLASE Compound cAMP-specific 3',5'-cyclic phosphodiesterase 4D Source (PDE4D_HUMAN) Sequence D:  QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQ ERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAAD VVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCD IFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEK SQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ STIP Description Functional site 1) chain D residue 391 type sequence D description binding site for residue EDO A 506 source : AC6 2) chain D residue 257 type sequence R description binding site for residue EDO A 515 source : AD6 3) chain D residue 152 type sequence H description binding site for residue EDO B 509 source : AF3 4) chain D residue 215 type sequence T description binding site for residue PEG B 511 source : AF5 5) chain D residue 217 type sequence S description binding site for residue PEG B 511 source : AF5 6) chain D residue 218 type sequence E description binding site for residue PEG B 511 source : AF5 7) chain D residue 219 type sequence L description binding site for residue PEG B 511 source : AF5 8) chain D residue 239 type sequence K description binding site for residue EDO B 515 source : AF9 9) chain D residue 224 type sequence N description binding site for residue EDO C 504 source : AG5 10) chain D residue 226 type sequence S description binding site for residue EDO C 504 source : AG5 11) chain D residue 258 type sequence Q description binding site for residue PEG C 511 source : AH3 12) chain D residue 262 type sequence K description binding site for residue PEG C 511 source : AH3 13) chain D residue 182 type sequence E description binding site for residue EDO D 501 source : AH7 14) chain D residue 177 type sequence S description binding site for residue DMS D 502 source : AH8 15) chain D residue 179 type sequence P description binding site for residue DMS D 502 source : AH8 16) chain D residue 182 type sequence E description binding site for residue DMS D 502 source : AH8 17) chain D residue 148 type sequence T description binding site for residue EDO D 503 source : AH9 18) chain D residue 152 type sequence H description binding site for residue EDO D 503 source : AH9 19) chain D residue 243 type sequence E description binding site for residue EDO D 503 source : AH9 20) chain D residue 179 type sequence P description binding site for residue EDO D 504 source : AI1 21) chain D residue 391 type sequence D description binding site for residue EDO D 504 source : AI1 22) chain D residue 175 type sequence L description binding site for residue EDO D 505 source : AI2 23) chain D residue 178 type sequence T description binding site for residue EDO D 505 source : AI2 24) chain D residue 391 type sequence D description binding site for residue EDO D 505 source : AI2 25) chain D residue 181 type sequence L description binding site for residue EDO D 506 source : AI3 26) chain D residue 183 type sequence A description binding site for residue EDO D 506 source : AI3 27) chain D residue 184 type sequence V description binding site for residue EDO D 506 source : AI3 28) chain D residue 185 type sequence F description binding site for residue EDO D 506 source : AI3 29) chain D residue 150 type sequence E description binding site for residue DMS D 507 source : AI4 30) chain D residue 151 type sequence D description binding site for residue DMS D 507 source : AI4 31) chain D residue 153 type sequence Y description binding site for residue DMS D 507 source : AI4 32) chain D residue 162 type sequence N description binding site for residue DMS D 507 source : AI4 33) chain D residue 100 type sequence N description binding site for residue EDO D 508 source : AI5 34) chain D residue 101 type sequence K description binding site for residue EDO D 508 source : AI5 35) chain D residue 102 type sequence W description binding site for residue EDO D 508 source : AI5 36) chain D residue 123 type sequence H description binding site for residue EDO D 509 source : AI6 37) chain D residue 156 type sequence D description binding site for residue EDO D 510 source : AI7 38) chain D residue 157 type sequence V description binding site for residue EDO D 510 source : AI7 39) chain D residue 158 type sequence A description binding site for residue EDO D 510 source : AI7 40) chain D residue 342 type sequence R description binding site for residue EDO D 510 source : AI7 41) chain D residue 134 type sequence T description binding site for residue EDO D 511 source : AI8 42) chain D residue 251 type sequence N description binding site for residue EDO D 511 source : AI8 43) chain D residue 256 type sequence Q description binding site for residue EDO D 511 source : AI8 44) chain D residue 164 type sequence H description binding site for residue ZN D 512 source : AI9 45) chain D residue 200 type sequence H description binding site for residue ZN D 512 source : AI9 46) chain D residue 201 type sequence D description binding site for residue ZN D 512 source : AI9 47) chain D residue 318 type sequence D description binding site for residue ZN D 512 source : AI9 48) chain D residue 98 type sequence D description binding site for residue EDO D 513 source : AJ1 49) chain D residue 102 type sequence W description binding site for residue EDO D 513 source : AJ1 50) chain D residue 266 type sequence D description binding site for residue EDO D 514 source : AJ2 51) chain D residue 311 type sequence Q description binding site for residue EDO D 514 source : AJ2 52) chain D residue 273 type sequence M description binding site for residue FFZ D 515 source : AJ3 53) chain D residue 321 type sequence N description binding site for residue FFZ D 515 source : AJ3 54) chain D residue 336 type sequence I description binding site for residue FFZ D 515 source : AJ3 55) chain D residue 368 type sequence S description binding site for residue FFZ D 515 source : AJ3 56) chain D residue 369 type sequence Q description binding site for residue FFZ D 515 source : AJ3 57) chain D residue 371 type sequence G description binding site for residue FFZ D 515 source : AJ3 58) chain D residue 372 type sequence F description binding site for residue FFZ D 515 source : AJ3 59) chain D residue 201 type sequence D description binding site for residue MG D 516 source : AJ4 60) chain D residue 221 type sequence L description binding site for residue EDO D 517 source : AJ5 61) chain D residue 222 type sequence M description binding site for residue EDO D 517 source : AJ5 62) chain D residue 224 type sequence N description binding site for residue EDO D 517 source : AJ5 63) chain D residue 140 type sequence D description binding site for residue EDO D 518 source : AJ6 64) chain D residue 143 type sequence I description binding site for residue EDO D 518 source : AJ6 65) chain D residue 144 type sequence T description binding site for residue EDO D 518 source : AJ6 66) chain D residue 238 type sequence F description binding site for residue EDO D 519 source : AJ7 67) chain D residue 249 type sequence F description binding site for residue EDO D 519 source : AJ7 68) chain D residue 257 type sequence R description binding site for residue EDO D 519 source : AJ7 69) chain D residue 261 type sequence R description binding site for residue EDO D 519 source : AJ7 70) chain D residue 289 type sequence T description binding site for residue EDO D 520 source : AJ8 71) chain D residue 290 type sequence K description binding site for residue EDO D 520 source : AJ8 72) chain D residue 291 type sequence K description binding site for residue EDO D 520 source : AJ8 73) chain D residue 298 type sequence L description binding site for residue EDO D 520 source : AJ8 74) chain D residue 299 type sequence L description binding site for residue EDO D 520 source : AJ8 75) chain D residue 186 type sequence T description binding site for residue EDO D 521 source : AJ9 76) chain D residue 189 type sequence E description binding site for residue EDO D 521 source : AJ9 77) chain D residue 259 type sequence S description binding site for residue EDO D 521 source : AJ9 78) chain D residue 263 type sequence M description binding site for residue EDO D 521 source : AJ9 79) chain D residue 183 type sequence A description binding site for residue EDO D 522 source : AK1 80) chain D residue 184 type sequence V description binding site for residue EDO D 522 source : AK1 81) chain D residue 105 type sequence H description binding site for residue EPE D 523 source : AK2 82) chain D residue 106 type sequence V description binding site for residue EPE D 523 source : AK2 83) chain D residue 107 type sequence F description binding site for residue EPE D 523 source : AK2 84) chain D residue 108 type sequence R description binding site for residue EPE D 523 source : AK2 85) chain D residue 111 type sequence E description binding site for residue EPE D 523 source : AK2 86) chain D residue 327 type sequence Q description binding site for residue EPE D 523 source : AK2 87) chain D residue 328 type sequence L description binding site for residue EPE D 523 source : AK2 88) chain D residue 331 type sequence Q description binding site for residue EPE D 523 source : AK2 89) chain D residue 136 type sequence K description binding site for residue PEG D 524 source : AK3 90) chain D residue 137 type sequence I description binding site for residue PEG D 524 source : AK3 91) chain D residue 139 type sequence V description binding site for residue PEG D 524 source : AK3 92) chain D residue 160 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 93) chain D residue 160 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 94) chain D residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 95) chain D residue 369 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 96) chain D residue 164 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3 97) chain D residue 200 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 98) chain D residue 318 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 99) chain D residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 100) chain D residue 372 type BINDING sequence F description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5

Display surface Download Links