|
|
eF-site ID
|
6hwd-W |
|
PDB Code
|
6hwd |
|
Chain
|
W |
|
click to enlarge
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|
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Title
|
Yeast 20S proteasome beta2-G45A mutant in complex with bortezomib |
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Classification
|
HYDROLASE |
|
Compound
|
Proteasome subunit alpha type-2 |
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Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae S288c; |
|
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Sequence
|
W: |
SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFE
KIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERA
IEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFI
AGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPE
DLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLK
MRQD
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
W |
| residue |
204 |
| type |
|
| sequence |
D
|
| description |
binding site for residue MG K 302
|
| source |
: AC7
|
|
|
2)
|
chain |
W |
| residue |
174 |
| type |
|
| sequence |
A
|
| description |
binding site for residue MG W 301
|
| source |
: AD3
|
|
|
3)
|
chain |
W |
| residue |
177 |
| type |
|
| sequence |
D
|
| description |
binding site for residue MG W 301
|
| source |
: AD3
|
|
|
4)
|
chain |
W |
| residue |
180 |
| type |
|
| sequence |
S
|
| description |
binding site for residue MG W 301
|
| source |
: AD3
|
|
|
5)
|
chain |
W |
| residue |
204 |
| type |
|
| sequence |
D
|
| description |
binding site for residue MG W 301
|
| source |
: AD3
|
|
|
6)
|
chain |
W |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
binding site for Di-peptide BO2 V 301 and THR V 1
|
| source |
: AD5
|
|
|
7)
|
chain |
W |
| residue |
69 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|