eF-site ID 6hwd-H PDB Code 6hwd Chain H click to enlarge Title Yeast 20S proteasome beta2-G45A mutant in complex with bortezomib Classification HYDROLASE Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae S288c; Sequence H:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAAAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICDIQEE Description Functional site 1) chain H residue 69 type sequence Y description binding site for residue CL G 302 source : AC2 2) chain H residue 1 type sequence T description binding site for residue BO2 H 301 source : AC3 3) chain H residue 20 type sequence S description binding site for residue BO2 H 301 source : AC3 4) chain H residue 21 type sequence T description binding site for residue BO2 H 301 source : AC3 5) chain H residue 31 type sequence C description binding site for residue BO2 H 301 source : AC3 6) chain H residue 46 type sequence A description binding site for residue BO2 H 301 source : AC3 7) chain H residue 47 type sequence G description binding site for residue BO2 H 301 source : AC3 8) chain H residue 49 type sequence A description binding site for residue BO2 H 301 source : AC3 9) chain H residue 52 type sequence T description binding site for residue BO2 H 301 source : AC3 10) chain H residue 118 type sequence S description binding site for residue BO2 N 201 source : AC9 11) chain H residue 4-51 type prosite sequence VGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWC AAAGTAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVtFkdGVILGADsrtttgayianrvtd.KltrvhdkiwccrsGsaAD source prosite : PS00854 12) chain H residue 1 type catalytic sequence T description 177 source MCSA : MCSA1 13) chain H residue 17 type catalytic sequence D description 177 source MCSA : MCSA1 14) chain H residue 19 type catalytic sequence R description 177 source MCSA : MCSA1 15) chain H residue 33 type catalytic sequence K description 177 source MCSA : MCSA1 16) chain H residue 47 type catalytic sequence G description 177 source MCSA : MCSA1 17) chain H residue 129 type catalytic sequence S description 177 source MCSA : MCSA1 18) chain H residue 166 type catalytic sequence D description 177 source MCSA : MCSA1 19) chain H residue 169 type catalytic sequence S description 177 source MCSA : MCSA1

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