eF-site ID 6hv0-A PDB Code 6hv0 Chain A click to enlarge Title IRE1 kinase/RNase in complex with imidazo[1,2-b]pyridazin-8-amine compound 33 Classification SIGNALING PROTEIN Compound Serine/threonine-protein kinase/endoribonuclease IRE1 Source (ERN1_HUMAN) Sequence A:  SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRI LPECSDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVE QKDFGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILIS MPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW IAPEMNPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQAN ILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAK HVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLER GGRAVVKMDWRENITVPLQTDLRRTYKGGSVRDLLRAMRN KKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYR AMELCSHERLFQPYYFH Description Functional site 1) chain A residue 577 type sequence L description binding site for residue GUK A 1001 source : AC1 2) chain A residue 586 type sequence V description binding site for residue GUK A 1001 source : AC1 3) chain A residue 588 type sequence R description binding site for residue GUK A 1001 source : AC1 4) chain A residue 599 type sequence K description binding site for residue GUK A 1001 source : AC1 5) chain A residue 626 type sequence I description binding site for residue GUK A 1001 source : AC1 6) chain A residue 628 type sequence Y description binding site for residue GUK A 1001 source : AC1 7) chain A residue 642 type sequence I description binding site for residue GUK A 1001 source : AC1 8) chain A residue 643 type sequence E description binding site for residue GUK A 1001 source : AC1 9) chain A residue 644 type sequence L description binding site for residue GUK A 1001 source : AC1 10) chain A residue 645 type sequence C description binding site for residue GUK A 1001 source : AC1 11) chain A residue 646 type sequence A description binding site for residue GUK A 1001 source : AC1 12) chain A residue 712 type sequence F description binding site for residue GUK A 1001 source : AC1 13) chain A residue 714 type sequence L description binding site for residue GUK A 1001 source : AC1 14) chain A residue 723 type sequence H description binding site for residue GUK A 1001 source : AC1 15) chain A residue 684-696 type prosite sequence IVHRDLKPHNILI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKphNILI source prosite : PS00108 16) chain A residue 688 type ACT_SITE sequence D description Proton acceptor => ECO:0000250|UniProtKB:P32361, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 577 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P32361, ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 599 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:9637683, ECO:0007744|PDB:3P23 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 643 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21317875, ECO:0007744|PDB:3P23 source Swiss-Prot : SWS_FT_FI4 20) chain A residue 690 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21317875, ECO:0007744|PDB:3P23 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 711 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21317875, ECO:0007744|PDB:3P23 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 892 type SITE sequence Y description Interacts with hydroxy-aryl-aldehyde inhibitors => ECO:0000250|UniProtKB:Q9EQY0 source Swiss-Prot : SWS_FT_FI5 23) chain A residue 724 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:30118681 source Swiss-Prot : SWS_FT_FI6 24) chain A residue 729 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:30118681 source Swiss-Prot : SWS_FT_FI6

Display surface Download Links