eF-site ID 6huy-ABCD PDB Code 6huy Chain A, B, C, D click to enlarge Title HmdII from Desulfurobacterium thermolithotrophum reconstitued with Fe-guanylylpyridinol (FeGP) cofactor and co-crystallized with methenyl-tetrahydrofolate form A Classification OXIDOREDUCTASE Compound Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase-related protein Source (F0S2B6_DESTD) Sequence A:  MRVTVYGFGSLNYYSNKLNVPEKLGGEPPYGGSAMAVEFA KAGHDVTLSDPNIDKVPDEIRKKVEDAGVKLTTDDIEAAK EAEVAILFTPFRGGVTFKIAETILPYLVENAVICTTCTMS ILVLNSYLQNAIFLEGREDIGFSTMHPAAIPGTPQHKHYL IATNELLRKPIVTEEQIEKLKKLATDTGKEAYLLPAELVS PVGDMGIVTTAIAFAGAIEYYKVSRDILKTKRSMTEFQIA QSLQVISSLVTKYGLEGLIKLLNVDAMKASLQSMILDKNE QPLTVTASKLLEKIEETIPELIKEAENFSPSEPTYTSAPS PMLVEHMEDLVGDDVLKGILRESWKKFYEN B:  MRVTVYGFGSLNYYSNKLNVPEKLGGEPPYGGSAMAVEFA KAGHDVTLSDPNIDKVPDEIRKKVEDAGVKLTTDDIEAAK EAEVAILFTPFRGGVTFKIAETILPYLVENAVICTTXTMS ILVLNSYLQNAIFLEGREDIGFSTMHPAAIPGTPQHKHYL IATNELLRKPIVTEEQIEKLKKLATDTGKEAYLLPAELVS PVGDMGIVTTAIAFAGAIEYYKVSRDILKTKRSMTEFQIA QSLQVISSLVTKYGLEGLIKLLNVDAMKASLQSMILDKNE QPLTVTASKLLEKIEETIPELIKEAENFSPSEPTYTSAPS PMLVEHMEDLVGDDVLKGILRESWKKFYENVSERNKE C:  MRVTVYGFGSLNYYSNKLNVPEKLGGEPPYGGSAMAVEFA KAGHDVTLSDPNIDKVPDEIRKKVEDAGVKLTTDDIEAAK EAEVAILFTPFRGGVTFKIAETILPYLVENAVICTTCTMS ILVLNSYLQNAIFLEGREDIGFSTMHPAAIPGTPQHKHYL IATNELLRKPIVTEEQIEKLKKLATDTGKEAYLLPAELVS PVGDMGIVTTAIAFAGAIEYYKVSRDILKTKRSMTEFQIA QSLQVISSLVTKYGLEGLIKLLNVDAMKASLQSMILDKNE QPLTVTASKLLEKIEETIPELIKEAENFSPSEPTYTSAPS PMLVEHMEDLVGDDVLKGILRESWKKFYENV D:  MRVTVYGFGSLNYYSNKLNVPEKLGGEPPYGGSAMAVEFA KAGHDVTLSDPNIDKVPDEIRKKVEDAGVKLTTDDIEAAK EAEVAILFTPFRGGVTFKIAETILPYLVENAVICTTXTMS ILVLNSYLQNAIFLEGREDIGFSTMHPAAIPGTPQHKHYL IATNELLRKPIVTEEQIEKLKKLATDTGKEAYLLPAELVS PVGDMGIVTTAIAFAGAIEYYKVSRDILKTKRSMTEFQIA QSLQVISSLVTKYGLEGLIKLLNVDAMKASLQSMILDKNE QPLTVTASKLLEKIEETIPELIKEAENFSPSEPTYTSAPS PMLVEHMEDLVGDDVLKGILRESWKKFYENVSERN Description Functional site 1) chain A residue 6 type sequence Y description binding site for residue FE9 A 401 source : AC1 2) chain A residue 8 type sequence F description binding site for residue FE9 A 401 source : AC1 3) chain A residue 9 type sequence G description binding site for residue FE9 A 401 source : AC1 4) chain A residue 10 type sequence S description binding site for residue FE9 A 401 source : AC1 5) chain A residue 14 type sequence Y description binding site for residue FE9 A 401 source : AC1 6) chain A residue 49 type sequence S description binding site for residue FE9 A 401 source : AC1 7) chain A residue 50 type sequence D description binding site for residue FE9 A 401 source : AC1 8) chain A residue 51 type sequence P description binding site for residue FE9 A 401 source : AC1 9) chain A residue 75 type sequence D description binding site for residue FE9 A 401 source : AC1 10) chain A residue 88 type sequence F description binding site for residue FE9 A 401 source : AC1 11) chain A residue 89 type sequence T description binding site for residue FE9 A 401 source : AC1 12) chain A residue 90 type sequence P description binding site for residue FE9 A 401 source : AC1 13) chain A residue 95 type sequence V description binding site for residue FE9 A 401 source : AC1 14) chain A residue 99 type sequence I description binding site for residue FE9 A 401 source : AC1 15) chain A residue 116 type sequence T description binding site for residue FE9 A 401 source : AC1 16) chain A residue 117 type sequence C description binding site for residue FE9 A 401 source : AC1 17) chain A residue 118 type sequence T description binding site for residue FE9 A 401 source : AC1 18) chain A residue 146 type sequence H description binding site for residue FE9 A 401 source : AC1 19) chain A residue 147 type sequence P description binding site for residue FE9 A 401 source : AC1 20) chain A residue 149 type sequence A description binding site for residue FE9 A 401 source : AC1 21) chain A residue 150 type sequence I description binding site for residue FE9 A 401 source : AC1 22) chain A residue 151 type sequence P description binding site for residue FE9 A 401 source : AC1 23) chain A residue 138 type sequence E description binding site for residue GOL A 402 source : AC2 24) chain A residue 140 type sequence I description binding site for residue GOL A 402 source : AC2 25) chain A residue 170 type sequence P description binding site for residue GOL A 402 source : AC2 26) chain A residue 171 type sequence I description binding site for residue GOL A 402 source : AC2 27) chain A residue 172 type sequence V description binding site for residue GOL A 402 source : AC2 28) chain A residue 173 type sequence T description binding site for residue GOL A 402 source : AC2 29) chain A residue 13 type sequence Y description binding site for residue GUE A 403 source : AC3 30) chain A residue 17 type sequence K description binding site for residue GUE A 403 source : AC3 31) chain A residue 91 type sequence F description binding site for residue GUE A 403 source : AC3 32) chain A residue 92 type sequence R description binding site for residue GUE A 403 source : AC3 33) chain A residue 148 type sequence A description binding site for residue GUE A 403 source : AC3 34) chain A residue 203 type sequence G description binding site for residue GUE A 403 source : AC3 35) chain A residue 204 type sequence D description binding site for residue GUE A 403 source : AC3 36) chain A residue 205 type sequence M description binding site for residue GUE A 403 source : AC3 37) chain B residue 229 type sequence K description binding site for residue GUE A 403 source : AC3 38) chain B residue 230 type sequence T description binding site for residue GUE A 403 source : AC3 39) chain B residue 234 type sequence M description binding site for residue GUE A 403 source : AC3 40) chain B residue 270 type sequence S description binding site for residue GUE A 403 source : AC3 41) chain B residue 273 type sequence S description binding site for residue GUE A 403 source : AC3 42) chain B residue 274 type sequence M description binding site for residue GUE A 403 source : AC3 43) chain B residue 9 type sequence G description binding site for residue DMS B 401 source : AC4 44) chain B residue 10 type sequence S description binding site for residue DMS B 401 source : AC4 45) chain B residue 11 type sequence L description binding site for residue DMS B 401 source : AC4 46) chain B residue 52 type sequence N description binding site for residue DMS B 401 source : AC4 47) chain B residue 55 type sequence K description binding site for residue DMS B 401 source : AC4 48) chain B residue 10 type sequence S description binding site for residue DMS B 402 source : AC5 49) chain B residue 14 type sequence Y description binding site for residue DMS B 402 source : AC5 50) chain B residue 138 type sequence E description binding site for residue DMS B 403 source : AC6 51) chain B residue 172 type sequence V description binding site for residue DMS B 403 source : AC6 52) chain B residue 173 type sequence T description binding site for residue DMS B 403 source : AC6 53) chain B residue 53 type sequence I description binding site for residue DMS B 404 source : AC7 54) chain B residue 54 type sequence D description binding site for residue DMS B 404 source : AC7 55) chain B residue 61 type sequence R description binding site for residue DMS B 404 source : AC7 56) chain B residue 71 type sequence L description binding site for residue DMS B 404 source : AC7 57) chain B residue 134 type sequence L description binding site for residue PG4 B 405 source : AC8 58) chain B residue 135 type sequence E description binding site for residue PG4 B 405 source : AC8 59) chain A residue 230 type sequence T description binding site for residue GUE B 406 source : AC9 60) chain A residue 234 type sequence M description binding site for residue GUE B 406 source : AC9 61) chain A residue 270 type sequence S description binding site for residue GUE B 406 source : AC9 62) chain A residue 273 type sequence S description binding site for residue GUE B 406 source : AC9 63) chain A residue 274 type sequence M description binding site for residue GUE B 406 source : AC9 64) chain B residue 13 type sequence Y description binding site for residue GUE B 406 source : AC9 65) chain B residue 90 type sequence P description binding site for residue GUE B 406 source : AC9 66) chain B residue 91 type sequence F description binding site for residue GUE B 406 source : AC9 67) chain B residue 92 type sequence R description binding site for residue GUE B 406 source : AC9 68) chain B residue 117 type sequence X description binding site for residue GUE B 406 source : AC9 69) chain B residue 118 type sequence T description binding site for residue GUE B 406 source : AC9 70) chain B residue 148 type sequence A description binding site for residue GUE B 406 source : AC9 71) chain B residue 150 type sequence I description binding site for residue GUE B 406 source : AC9 72) chain B residue 203 type sequence G description binding site for residue GUE B 406 source : AC9 73) chain B residue 204 type sequence D description binding site for residue GUE B 406 source : AC9 74) chain B residue 205 type sequence M description binding site for residue GUE B 406 source : AC9 75) chain C residue 6 type sequence Y description binding site for residue FE9 C 401 source : AD1 76) chain C residue 8 type sequence F description binding site for residue FE9 C 401 source : AD1 77) chain C residue 9 type sequence G description binding site for residue FE9 C 401 source : AD1 78) chain C residue 10 type sequence S description binding site for residue FE9 C 401 source : AD1 79) chain C residue 14 type sequence Y description binding site for residue FE9 C 401 source : AD1 80) chain C residue 49 type sequence S description binding site for residue FE9 C 401 source : AD1 81) chain C residue 50 type sequence D description binding site for residue FE9 C 401 source : AD1 82) chain C residue 51 type sequence P description binding site for residue FE9 C 401 source : AD1 83) chain C residue 75 type sequence D description binding site for residue FE9 C 401 source : AD1 84) chain C residue 88 type sequence F description binding site for residue FE9 C 401 source : AD1 85) chain C residue 89 type sequence T description binding site for residue FE9 C 401 source : AD1 86) chain C residue 90 type sequence P description binding site for residue FE9 C 401 source : AD1 87) chain C residue 95 type sequence V description binding site for residue FE9 C 401 source : AD1 88) chain C residue 99 type sequence I description binding site for residue FE9 C 401 source : AD1 89) chain C residue 116 type sequence T description binding site for residue FE9 C 401 source : AD1 90) chain C residue 117 type sequence C description binding site for residue FE9 C 401 source : AD1 91) chain C residue 118 type sequence T description binding site for residue FE9 C 401 source : AD1 92) chain C residue 146 type sequence H description binding site for residue FE9 C 401 source : AD1 93) chain C residue 147 type sequence P description binding site for residue FE9 C 401 source : AD1 94) chain C residue 148 type sequence A description binding site for residue FE9 C 401 source : AD1 95) chain C residue 149 type sequence A description binding site for residue FE9 C 401 source : AD1 96) chain C residue 150 type sequence I description binding site for residue FE9 C 401 source : AD1 97) chain C residue 151 type sequence P description binding site for residue FE9 C 401 source : AD1 98) chain C residue 138 type sequence E description binding site for residue DMS C 402 source : AD2 99) chain C residue 139 type sequence D description binding site for residue DMS C 402 source : AD2 100) chain C residue 140 type sequence I description binding site for residue DMS C 402 source : AD2 101) chain C residue 171 type sequence I description binding site for residue DMS C 402 source : AD2 102) chain C residue 166 type sequence L description binding site for residue DMS C 403 source : AD3 103) chain C residue 167 type sequence L description binding site for residue DMS C 403 source : AD3 104) chain D residue 310 type sequence P description binding site for residue DMS C 403 source : AD3 105) chain D residue 312 type sequence E description binding site for residue DMS C 403 source : AD3 106) chain D residue 313 type sequence P description binding site for residue DMS C 403 source : AD3 107) chain C residue 13 type sequence Y description binding site for residue GUE C 404 source : AD4 108) chain C residue 17 type sequence K description binding site for residue GUE C 404 source : AD4 109) chain C residue 91 type sequence F description binding site for residue GUE C 404 source : AD4 110) chain C residue 92 type sequence R description binding site for residue GUE C 404 source : AD4 111) chain C residue 148 type sequence A description binding site for residue GUE C 404 source : AD4 112) chain C residue 203 type sequence G description binding site for residue GUE C 404 source : AD4 113) chain C residue 204 type sequence D description binding site for residue GUE C 404 source : AD4 114) chain C residue 205 type sequence M description binding site for residue GUE C 404 source : AD4 115) chain D residue 230 type sequence T description binding site for residue GUE C 404 source : AD4 116) chain D residue 234 type sequence M description binding site for residue GUE C 404 source : AD4 117) chain D residue 270 type sequence S description binding site for residue GUE C 404 source : AD4 118) chain D residue 273 type sequence S description binding site for residue GUE C 404 source : AD4 119) chain D residue 274 type sequence M description binding site for residue GUE C 404 source : AD4 120) chain D residue 40 type sequence A description binding site for residue GOL D 401 source : AD5 121) chain D residue 41 type sequence K description binding site for residue GOL D 401 source : AD5 122) chain D residue 67 type sequence A description binding site for residue GOL D 401 source : AD5 123) chain D residue 9 type sequence G description binding site for residue DMS D 402 source : AD6 124) chain D residue 10 type sequence S description binding site for residue DMS D 402 source : AD6 125) chain D residue 11 type sequence L description binding site for residue DMS D 402 source : AD6 126) chain D residue 52 type sequence N description binding site for residue DMS D 402 source : AD6 127) chain D residue 10 type sequence S description binding site for residue DMS D 403 source : AD7 128) chain D residue 14 type sequence Y description binding site for residue DMS D 403 source : AD7 129) chain D residue 138 type sequence E description binding site for residue DMS D 404 source : AD8 130) chain D residue 170 type sequence P description binding site for residue DMS D 404 source : AD8 131) chain D residue 171 type sequence I description binding site for residue DMS D 404 source : AD8 132) chain D residue 172 type sequence V description binding site for residue DMS D 404 source : AD8 133) chain C residue 230 type sequence T description binding site for residue GUE D 405 source : AD9 134) chain C residue 234 type sequence M description binding site for residue GUE D 405 source : AD9 135) chain C residue 270 type sequence S description binding site for residue GUE D 405 source : AD9 136) chain C residue 273 type sequence S description binding site for residue GUE D 405 source : AD9 137) chain C residue 274 type sequence M description binding site for residue GUE D 405 source : AD9 138) chain D residue 13 type sequence Y description binding site for residue GUE D 405 source : AD9 139) chain D residue 90 type sequence P description binding site for residue GUE D 405 source : AD9 140) chain D residue 91 type sequence F description binding site for residue GUE D 405 source : AD9 141) chain D residue 92 type sequence R description binding site for residue GUE D 405 source : AD9 142) chain D residue 117 type sequence X description binding site for residue GUE D 405 source : AD9 143) chain D residue 118 type sequence T description binding site for residue GUE D 405 source : AD9 144) chain D residue 148 type sequence A description binding site for residue GUE D 405 source : AD9 145) chain D residue 150 type sequence I description binding site for residue GUE D 405 source : AD9 146) chain D residue 203 type sequence G description binding site for residue GUE D 405 source : AD9 147) chain D residue 204 type sequence D description binding site for residue GUE D 405 source : AD9 148) chain D residue 205 type sequence M description binding site for residue GUE D 405 source : AD9

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