eF-site ID 6hks-ABCDEFGHIJKL PDB Code 6hks Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide Classification HYDROLASE Compound Tyrosine-protein phosphatase non-receptor type 3 Source (VE6_HPV16) Sequence A:  DSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPES PADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE SHSRELALVIRRR B:  GDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPE SPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASR ESHSRELALVIRRR C:  SYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESP ADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRES HSRELALVIRR D:  DSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPES PADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE SHSRELALVIRR E:  DSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPES PADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE SHSRELALVIRRR F:  DSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPES PADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE SHSRELALVIRRR G:  TRRETQL H:  RRETQL I:  RRETQL J:  RRETQL K:  RRETQL L:  TRRETQL Description Functional site 1) chain C residue 564 type sequence G description binding site for residue IOD A 601 source : AC1 2) chain B residue 551 type sequence P description binding site for residue IOD B 601 source : AC2 3) chain B residue 552 type sequence K description binding site for residue IOD B 601 source : AC2 4) chain B residue 596 type sequence R description binding site for residue IOD B 601 source : AC2 5) chain D residue 564 type sequence G description binding site for residue IOD B 601 source : AC2 6) chain E residue 552 type sequence K description binding site for residue IOD E 601 source : AC3 7) chain F residue 552 type sequence K description binding site for residue IOD F 601 source : AC4

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