|
eF-site ID
|
6hks-ABCDEFGHIJKL |
PDB Code
|
6hks |
Chain
|
A, B, C, D, E, F, G, H, I, J, K, L |
|
click to enlarge
|
|
Title
|
Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide |
Classification
|
HYDROLASE |
Compound
|
Tyrosine-protein phosphatase non-receptor type 3 |
Source
|
(VE6_HPV16) |
|
Sequence
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A: |
DSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPES
PADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE
SHSRELALVIRRR
|
B: |
GDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPE
SPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASR
ESHSRELALVIRRR
|
C: |
SYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESP
ADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRES
HSRELALVIRR
|
D: |
DSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPES
PADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE
SHSRELALVIRR
|
E: |
DSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPES
PADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE
SHSRELALVIRRR
|
F: |
DSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPES
PADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE
SHSRELALVIRRR
|
G: |
TRRETQL
|
H: |
RRETQL
|
I: |
RRETQL
|
J: |
RRETQL
|
K: |
RRETQL
|
L: |
TRRETQL
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
C |
residue |
564 |
type |
|
sequence |
G
|
description |
binding site for residue IOD A 601
|
source |
: AC1
|
|
2)
|
chain |
B |
residue |
551 |
type |
|
sequence |
P
|
description |
binding site for residue IOD B 601
|
source |
: AC2
|
|
3)
|
chain |
B |
residue |
552 |
type |
|
sequence |
K
|
description |
binding site for residue IOD B 601
|
source |
: AC2
|
|
4)
|
chain |
B |
residue |
596 |
type |
|
sequence |
R
|
description |
binding site for residue IOD B 601
|
source |
: AC2
|
|
5)
|
chain |
D |
residue |
564 |
type |
|
sequence |
G
|
description |
binding site for residue IOD B 601
|
source |
: AC2
|
|
6)
|
chain |
E |
residue |
552 |
type |
|
sequence |
K
|
description |
binding site for residue IOD E 601
|
source |
: AC3
|
|
7)
|
chain |
F |
residue |
552 |
type |
|
sequence |
K
|
description |
binding site for residue IOD F 601
|
source |
: AC4
|
|
|
|