eF-site ID 6hk7-A PDB Code 6hk7 Chain A click to enlarge Title Crystal structure of GSK-3B in complex with pyrazine inhibitor C50 Classification TRANSFERASE Compound Glycogen synthase kinase-3 beta Source (GSK3B_HUMAN) Sequence A:  KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKL CDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV LKLCDFGSAKQLVRGEPNVSXICSRYYRAPELIFGATDYT SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA LCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRD TPALFNFTTQELSSNPPLATILIPPHA Description Functional site 1) chain A residue 56 type sequence Y description binding site for residue GOL A 401 source : AC1 2) chain A residue 86 type sequence K description binding site for residue GOL A 401 source : AC1 3) chain A residue 118 type sequence S description binding site for residue GOL A 401 source : AC1 4) chain A residue 129 type sequence N description binding site for residue GOL A 401 source : AC1 5) chain A residue 185 type sequence Q description binding site for residue DMS A 402 source : AC2 6) chain A residue 199 type sequence C description binding site for residue DMS A 402 source : AC2 7) chain A residue 62 type sequence I description binding site for residue G8N A 403 source : AC3 8) chain A residue 67 type sequence F description binding site for residue G8N A 403 source : AC3 9) chain A residue 70 type sequence V description binding site for residue G8N A 403 source : AC3 10) chain A residue 83 type sequence A description binding site for residue G8N A 403 source : AC3 11) chain A residue 85 type sequence K description binding site for residue G8N A 403 source : AC3 12) chain A residue 133 type sequence D description binding site for residue G8N A 403 source : AC3 13) chain A residue 135 type sequence V description binding site for residue G8N A 403 source : AC3 14) chain A residue 136 type sequence P description binding site for residue G8N A 403 source : AC3 15) chain A residue 138 type sequence T description binding site for residue G8N A 403 source : AC3 16) chain A residue 141 type sequence R description binding site for residue G8N A 403 source : AC3 17) chain A residue 188 type sequence L description binding site for residue G8N A 403 source : AC3 18) chain A residue 200 type sequence D description binding site for residue G8N A 403 source : AC3 19) chain A residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 20) chain A residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 216 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 62-86 type prosite sequence IGNGSFGVVYQAKLCDSGELVAIKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK source prosite : PS00107 24) chain A residue 177-189 type prosite sequence ICHRDIKPQNLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL source prosite : PS00108

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