eF-site ID 6hk3-B PDB Code 6hk3 Chain B click to enlarge Title Crystal structure of GSK-3B in complex with pyrazine inhibitor C44 Classification TRANSFERASE Compound Glycogen synthase kinase-3 beta Source (6HK3) Sequence B:  SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK LCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA VLKLCDFGSAKQLVRGEPNVSXICSRYYRAPELIFGATDY TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAI ALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGR DTPALFNFTTQELSSNPPLATILIPPHARI Description Functional site 1) chain B residue 290 type sequence E description binding site for residue GOL A 403 source : AC3 2) chain B residue 83 type sequence A description binding site for residue G8B B 401 source : AC8 3) chain B residue 85 type sequence K description binding site for residue G8B B 401 source : AC8 4) chain B residue 110 type sequence V description binding site for residue G8B B 401 source : AC8 5) chain B residue 133 type sequence D description binding site for residue G8B B 401 source : AC8 6) chain B residue 134 type sequence Y description binding site for residue G8B B 401 source : AC8 7) chain B residue 135 type sequence V description binding site for residue G8B B 401 source : AC8 8) chain B residue 136 type sequence P description binding site for residue G8B B 401 source : AC8 9) chain B residue 141 type sequence R description binding site for residue G8B B 401 source : AC8 10) chain B residue 188 type sequence L description binding site for residue G8B B 401 source : AC8 11) chain B residue 200 type sequence D description binding site for residue G8B B 401 source : AC8 12) chain B residue 96 type sequence R description binding site for residue MLI B 402 source : AC9 13) chain B residue 180 type sequence R description binding site for residue MLI B 402 source : AC9 14) chain B residue 205 type sequence K description binding site for residue MLI B 402 source : AC9 15) chain B residue 213 type sequence N description binding site for residue MLI B 402 source : AC9 16) chain B residue 214 type sequence V description binding site for residue MLI B 402 source : AC9 17) chain B residue 56 type sequence Y description binding site for residue GOL B 403 source : AD1 18) chain B residue 86 type sequence K description binding site for residue GOL B 403 source : AD1 19) chain B residue 129 type sequence N description binding site for residue GOL B 403 source : AD1 20) chain B residue 106 type sequence H description binding site for residue CL B 404 source : AD2 21) chain B residue 366 type sequence E description binding site for residue CL B 404 source : AD2 22) chain B residue 157 type sequence Y description binding site for residue DMS B 405 source : AD3 23) chain B residue 161 type sequence Y description binding site for residue DMS B 405 source : AD3 24) chain B residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 26) chain B residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 216 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI4

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