eF-site ID 6hfy-ABCD
PDB Code 6hfy
Chain A, B, C, D

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Title Influenza A virus N6 neuraminidase complex with DANA (Duck/England/56).
Classification HYDROLASE
Compound Neuraminidase
Source ORGANISM_SCIENTIFIC: Influenza A virus (strain A/Duck/England/1/1956 H11N6);
Sequence A:  RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPY
LSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISW
EMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNN
ASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVV
MTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSK
VLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENS
WLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQ
NWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWT
SNSIVALCGSKKRLGSWSWHDGAEIIYFE
B:  RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPY
LSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISW
EMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNN
ASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVV
MTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSK
VLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENS
WLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQ
NWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWT
SNSIVALCGSKKRLGSWSWHDGAEIIYFE
C:  RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPY
LSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISW
EMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNN
ASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVV
MTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSK
VLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENS
WLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQ
NWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWT
SNSIVALCGSKKRLGSWSWHDGAEIIYFE
D:  RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPY
LSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISW
EMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNN
ASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVV
MTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSK
VLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENS
WLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQ
NWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWT
SNSIVALCGSKKRLGSWSWHDGAEIIYFE
Description


Functional site
1) chain A
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1
2) chain B
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1
3) chain C
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1
4) chain D
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1
5) chain A
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2
6) chain B
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2
7) chain C
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2
8) chain D
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2
9) chain A
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
10) chain B
residue 372
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
11) chain C
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
12) chain C
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
13) chain C
residue 277
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
14) chain C
residue 293
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
15) chain C
residue 372
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
16) chain D
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
17) chain D
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
18) chain D
residue 277
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
19) chain D
residue 293
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
20) chain A
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
21) chain D
residue 372
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
22) chain A
residue 277
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
23) chain A
residue 293
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
24) chain A
residue 372
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
25) chain B
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
26) chain B
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
27) chain B
residue 277
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
28) chain B
residue 293
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
29) chain A
residue 294
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
30) chain D
residue 294
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
31) chain D
residue 298
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
32) chain D
residue 325
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
33) chain A
residue 298
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
34) chain A
residue 325
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
35) chain B
residue 294
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
36) chain B
residue 298
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
37) chain B
residue 325
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
38) chain C
residue 294
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
39) chain C
residue 298
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
40) chain C
residue 325
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4
41) chain A
residue 348
type BINDING
sequence P
description BINDING => ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI5
42) chain B
residue 348
type BINDING
sequence P
description BINDING => ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI5
43) chain C
residue 348
type BINDING
sequence P
description BINDING => ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI5
44) chain D
residue 348
type BINDING
sequence P
description BINDING => ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI5
45) chain A
residue 86
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6
46) chain A
residue 201
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6
47) chain B
residue 86
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6
48) chain B
residue 201
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6
49) chain C
residue 86
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6
50) chain C
residue 201
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6
51) chain D
residue 86
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6
52) chain D
residue 201
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6
53) chain A
residue 146
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI7
54) chain B
residue 146
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI7
55) chain C
residue 146
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI7
56) chain D
residue 146
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI7
57) chain A
residue 402
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI8
58) chain B
residue 402
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI8
59) chain C
residue 402
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI8
60) chain D
residue 402
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI8

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