eF-site ID 6hei-AB PDB Code 6hei Chain A, B click to enlarge Title Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA Classification HYDROLASE Compound Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28 Source (UBB_HUMAN) Sequence A:  PNDWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLV LSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNR KFVDPSAALDLLKGAFEEQQQDVSEFTHKLLDWLEDAFQL AVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNNETF GQYPLQVNGYRNLDECLEGAMVGQERWFTKLPPVLTFELS RFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYGSGSGSRQV PYRLHAVLVHEGQANAGHYWAYIYNQPRQSWLKYNDISVT ESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFMSEVEAL SVELKHYIQEDNWRFEQEVEEWEEEQ B:  PMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPD QQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGX Description Functional site 1) chain A residue 182 type sequence Q description binding site for residue EDO A 801 source : AC1 2) chain A residue 184 type sequence P description binding site for residue EDO A 801 source : AC1 3) chain A residue 608 type sequence Q description binding site for residue EDO A 801 source : AC1 4) chain A residue 655 type sequence F description binding site for residue EDO A 801 source : AC1 5) chain A residue 163-178 type prosite sequence GLKNVGNTCWFSAVIQ description USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknvGNtCWFSAvIQ source prosite : PS00972 6) chain A residue 584-601 type prosite sequence YRLHAVLVHEGQANAGHY description USP_2 Ubiquitin specific protease (USP) domain signature 2. YrLhAVlvHeGqana..GHY source prosite : PS00973 7) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 8) chain A residue 171 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 9) chain A residue 600 type ACT_SITE sequence H description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 375 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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