eF-site ID 6hcx-A
PDB Code 6hcx
Chain A

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Title Influenza Virus N9 Neuraminidase A complex with Zanamivir molecule (Tern).
Classification HYDROLASE
Compound Neuraminidase
Source (NRAM_I75A5)
Sequence A:  RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPY
VSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISW
PLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNN
ASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVV
FTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSC
YGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSP
VLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTW
LGRTISIASRSGYEMLKVPNALTDDKSKPTQGQTIVLNTD
WSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTS
NSIVSMCSSTEFLGQWDWPDGAKIEYFL
Description


Functional site

1) chain A
residue 152
type catalytic
sequence D
description 828
source MCSA : MCSA1

2) chain A
residue 279
type catalytic
sequence E
description 828
source MCSA : MCSA1

3) chain A
residue 294
type catalytic
sequence R
description 828
source MCSA : MCSA1

4) chain A
residue 372
type catalytic
sequence R
description 828
source MCSA : MCSA1

5) chain A
residue 406
type catalytic
sequence Y
description 828
source MCSA : MCSA1

6) chain A
residue 152
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2

8) chain A
residue 119
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

9) chain A
residue 153
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

10) chain A
residue 278
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

11) chain A
residue 294
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

12) chain A
residue 372
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

13) chain A
residue 295
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:8371267, ECO:0000269|PubMed:9342319
source Swiss-Prot : SWS_FT_FI4

14) chain A
residue 299
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:8371267, ECO:0000269|PubMed:9342319
source Swiss-Prot : SWS_FT_FI4

15) chain A
residue 326
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:8371267, ECO:0000269|PubMed:9342319
source Swiss-Prot : SWS_FT_FI4

16) chain A
residue 348
type BINDING
sequence N
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:8371267, ECO:0000269|PubMed:9342319
source Swiss-Prot : SWS_FT_FI4

17) chain A
residue 87
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:9342319
source Swiss-Prot : SWS_FT_FI5

18) chain A
residue 147
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:9342319
source Swiss-Prot : SWS_FT_FI5

19) chain A
residue 202
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:9342319
source Swiss-Prot : SWS_FT_FI5


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