eF-site ID 6hb7-B PDB Code 6hb7 Chain B click to enlarge Title Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-N3-methyluridine Classification LIGASE Compound Tyrosine--tRNA ligase Source (A0A140NBN7_ECOBD) Sequence B:  SNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPT ADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPS FKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIA ANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNR EDQGISFTEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWG NITSGIDLTRRLHQNQVFGLTVPLITKADGTAVWLDPKKT SPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDK NSGKAPRAQYVLAEQVTRLVHGEEGLQAAKRITECLFSGS LSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPS RGQARKTIASNAITINGEKQSDPEYFFKEEERLFGRFTLL RRGKKNYCLICWK Description (1)  tyrosyl-tRNA synthetase Functional site 1) chain B residue 37 type sequence Y description binding site for residue Y3U B 501 source : AC6 2) chain B residue 39 type sequence G description binding site for residue Y3U B 501 source : AC6 3) chain B residue 41 type sequence D description binding site for residue Y3U B 501 source : AC6 4) chain B residue 50 type sequence G description binding site for residue Y3U B 501 source : AC6 5) chain B residue 51 type sequence H description binding site for residue Y3U B 501 source : AC6 6) chain B residue 54 type sequence P description binding site for residue Y3U B 501 source : AC6 7) chain B residue 71 type sequence L description binding site for residue Y3U B 501 source : AC6 8) chain B residue 76 type sequence T description binding site for residue Y3U B 501 source : AC6 9) chain B residue 81 type sequence D description binding site for residue Y3U B 501 source : AC6 10) chain B residue 175 type sequence Y description binding site for residue Y3U B 501 source : AC6 11) chain B residue 179 type sequence Q description binding site for residue Y3U B 501 source : AC6 12) chain B residue 182 type sequence D description binding site for residue Y3U B 501 source : AC6 13) chain B residue 195 type sequence Q description binding site for residue Y3U B 501 source : AC6 14) chain B residue 197 type sequence G description binding site for residue Y3U B 501 source : AC6 15) chain B residue 198 type sequence G description binding site for residue Y3U B 501 source : AC6 16) chain B residue 200 type sequence D description binding site for residue Y3U B 501 source : AC6 17) chain B residue 201 type sequence Q description binding site for residue Y3U B 501 source : AC6 18) chain B residue 225 type sequence V description binding site for residue Y3U B 501 source : AC6 19) chain B residue 226 type sequence P description binding site for residue Y3U B 501 source : AC6 20) chain B residue 227 type sequence L description binding site for residue Y3U B 501 source : AC6 21) chain B residue 144 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI6 22) chain B residue 37 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000305|PubMed:15671170 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 175 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000269|PubMed:15671170, ECO:0000305|PubMed:20159998 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 179 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000269|PubMed:15671170, ECO:0000305|PubMed:20159998 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 231 type SITE sequence A description Cross-linked with tRNA by periodate oxidation source Swiss-Prot : SWS_FT_FI4

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