eF-site ID 6har-AE PDB Code 6har Chain A, E click to enlarge Title Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C Classification PROTEIN FIBRIL Compound PRSS3 protein Source (H7C0V9_HUMAN) Sequence A:  IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAH CYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISG WGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM FCVGFLEGGKDSCQRDAGGPVVCNGQLQGVVSWGHGCAWK NRPGVYTKVYNYVDWIKDTIAANS E:  EVCSEQAETGPCRACFSRWYFDVTEGKCAPFCYGGCGGNR NNFDTEEYCMAVCG Description Functional site 1) chain A residue 97 type sequence D description binding site for residue EDO A 301 source : AC1 2) chain A residue 175 type sequence K description binding site for residue EDO A 301 source : AC1 3) chain A residue 217 type sequence H description binding site for residue EDO A 301 source : AC1 4) chain A residue 70 type sequence E description binding site for residue CA A 302 source : AC2 5) chain A residue 72 type sequence N description binding site for residue CA A 302 source : AC2 6) chain A residue 75 type sequence V description binding site for residue CA A 302 source : AC2 7) chain A residue 80 type sequence E description binding site for residue CA A 302 source : AC2 8) chain A residue 53-58 type prosite sequence VSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC source prosite : PS00134 9) chain E residue 33-51 type prosite sequence FCYGGCGGNRNNFDTEEYC description BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FcyGGCggnrnnFdteeyC source prosite : PS00280

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