eF-site ID 6h7s-AB PDB Code 6h7s Chain A, B click to enlarge Title Sulfolobus solfataricus 2-keto-3-deoxygluconate aldolase T157V/A198L variant in complex with L-2-keto-3deoxy-gluconate Classification LYASE Compound 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase Source (KDGA_SULSF) Sequence A:  PEIITPIITPFTKDNRIDKEKLKIHAENLIRKGIDKLFVN GTTGLGPSLSPEEKLENLKAVYDVTNKIIFQVGGLNLDDA IRLAKLSKDFDIVGIASYAPYYYPRMSEKHLVKYFKTLCE VSPHPVYLYNYPTATGKDIDAKVAKEIGCFTGVKDVIENI IHTLDYKRLNPNMLVYSGSDMLIATVASTGLDGNVALGSN YLPEVTVTIKKLAMERKIDEALKLQFLHDEVIEASRIFGS LSSNYVLTKYFQGYDLGYPRPPIFPLDDEEERQLIKKVEG IRAKLVELKILKE B:  PEIITPIITPFTKDNRIDKEKLKIHAENLIRKGIDKLFVN GTTGLGPSLSPEEKLENLKAVYDVTNKIIFQVGGLNLDDA IRLAKLSKDFDIVGIASYAPYYYPRMSEKHLVKYFKTLCE VSPHPVYLYNYPTATGKDIDAKVAKEIGCFTGVKDVIENI IHTLDYKRLNPNMLVYSGSDMLIATVASTGLDGNVALGSN YLPEVTVTIKKLAMERKIDEALKLQFLHDEVIEASRIFGS LSSNYVLTKYFQGYDLGYPRPPIFPLDDEEERQLIKKVEG IRAKLVELKILKE Description Functional site 1) chain A residue 7 type sequence P description binding site for residue FW2 A 301 source : AC1 2) chain A residue 39 type sequence F description binding site for residue FW2 A 301 source : AC1 3) chain A residue 42 type sequence G description binding site for residue FW2 A 301 source : AC1 4) chain A residue 43 type sequence T description binding site for residue FW2 A 301 source : AC1 5) chain A residue 44 type sequence T description binding site for residue FW2 A 301 source : AC1 6) chain A residue 130 type sequence Y description binding site for residue FW2 A 301 source : AC1 7) chain A residue 132 type sequence Y description binding site for residue FW2 A 301 source : AC1 8) chain A residue 155 type sequence K description binding site for residue FW2 A 301 source : AC1 9) chain A residue 179 type sequence G description binding site for residue FW2 A 301 source : AC1 10) chain A residue 196 type sequence V description binding site for residue FW2 A 301 source : AC1 11) chain B residue 7 type sequence P description binding site for residue FW2 B 301 source : AC2 12) chain B residue 43 type sequence T description binding site for residue FW2 B 301 source : AC2 13) chain B residue 44 type sequence T description binding site for residue FW2 B 301 source : AC2 14) chain B residue 130 type sequence Y description binding site for residue FW2 B 301 source : AC2 15) chain B residue 132 type sequence Y description binding site for residue FW2 B 301 source : AC2 16) chain B residue 155 type sequence K description binding site for residue FW2 B 301 source : AC2 17) chain B residue 179 type sequence G description binding site for residue FW2 B 301 source : AC2 18) chain B residue 198 type sequence L description binding site for residue FW2 B 301 source : AC2 19) chain A residue 155 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000269|PubMed:15265860 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 155 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000269|PubMed:15265860 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 43 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 22) chain A residue 130 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 23) chain A residue 155 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 24) chain B residue 43 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 25) chain B residue 130 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 26) chain B residue 155 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 27) chain A residue 130 type SITE sequence Y description Proton shuttle => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 130 type SITE sequence Y description Proton shuttle => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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