eF-site ID 6h4o-D PDB Code 6h4o Chain D click to enlarge Title Crystal structure of human KDM4A in complex with compound 18a Classification OXIDOREDUCTASE Compound Lysine-specific demethylase 4A Source (KDM4A_HUMAN) Sequence D:  ESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAG LAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFT QYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWK NLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGV NTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSV PPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLK KYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNF ATRRWIEYGKQAVLCSCMVKISMDVFVRKFQPERYKLWKA GKDNTVIDHTLPTPEAAEFL Description Functional site 1) chain D residue 75 type sequence V description binding site for residue GOL B 404 source : AC9 2) chain D residue 76 type sequence T description binding site for residue GOL B 404 source : AC9 3) chain D residue 77 type sequence G description binding site for residue GOL B 404 source : AC9 4) chain D residue 126 type sequence T description binding site for residue GOL B 404 source : AC9 5) chain D residue 127 type sequence F description binding site for residue GOL B 404 source : AC9 6) chain D residue 188 type sequence H description binding site for residue ZN D 401 source : AD7 7) chain D residue 190 type sequence E description binding site for residue ZN D 401 source : AD7 8) chain D residue 276 type sequence H description binding site for residue ZN D 401 source : AD7 9) chain D residue 234 type sequence C description binding site for residue ZN D 402 source : AD8 10) chain D residue 240 type sequence H description binding site for residue ZN D 402 source : AD8 11) chain D residue 306 type sequence C description binding site for residue ZN D 402 source : AD8 12) chain D residue 308 type sequence C description binding site for residue ZN D 402 source : AD8 13) chain D residue 132 type sequence Y description binding site for residue FQH D 403 source : AD9 14) chain D residue 135 type sequence D description binding site for residue FQH D 403 source : AD9 15) chain D residue 177 type sequence Y description binding site for residue FQH D 403 source : AD9 16) chain D residue 185 type sequence F description binding site for residue FQH D 403 source : AD9 17) chain D residue 188 type sequence H description binding site for residue FQH D 403 source : AD9 18) chain D residue 190 type sequence E description binding site for residue FQH D 403 source : AD9 19) chain D residue 206 type sequence K description binding site for residue FQH D 403 source : AD9 20) chain D residue 208 type sequence W description binding site for residue FQH D 403 source : AD9 21) chain D residue 276 type sequence H description binding site for residue FQH D 403 source : AD9 22) chain D residue 193 type sequence D description binding site for residue DMS D 404 source : AE1 23) chain D residue 217 type sequence K description binding site for residue DMS D 404 source : AE1 24) chain D residue 273 type sequence Y description binding site for residue DMS D 404 source : AE1 25) chain D residue 299 type sequence Y description binding site for residue DMS D 404 source : AE1 26) chain D residue 302 type sequence Q description binding site for residue DMS D 404 source : AE1 27) chain D residue 343 type sequence H description binding site for residue DMS D 404 source : AE1 28) chain D residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 32) chain D residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 33) chain D residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 34) chain D residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 35) chain D residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 36) chain D residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 37) chain D residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 38) chain D residue 170 type catalytic sequence G description 370 source MCSA : MCSA4 39) chain D residue 177 type catalytic sequence Y description 370 source MCSA : MCSA4 40) chain D residue 188 type catalytic sequence H description 370 source MCSA : MCSA4 41) chain D residue 190 type catalytic sequence E description 370 source MCSA : MCSA4 42) chain D residue 276 type catalytic sequence H description 370 source MCSA : MCSA4 43) chain D residue 288 type catalytic sequence S description 370 source MCSA : MCSA4 44) chain D residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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