eF-site ID 6h4o-ABC PDB Code 6h4o Chain A, B, C click to enlarge Title Crystal structure of human KDM4A in complex with compound 18a Classification OXIDOREDUCTASE Compound Lysine-specific demethylase 4A Source (KDM4A_HUMAN) Sequence A:  LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKV VPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNI QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTF NPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPY LYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEH GKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGI PFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRR WIEYGKQAVLCSCRKMVKISMDVFVRKFQPERYKLWKAGK DNTVIDHTLPTPEAAEFL B:  TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAK VVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYN IQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLT FNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEEGVNT PYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPP EHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKY GIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFAT RRWIEYGKQAVLCSCRMVKISMDVFVRKFQPERYKLWKAG KDNTVIDHTLPTPEAAEFL C:  SARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPP KEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPP IYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEG VNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYS VPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLML KKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTN FATRRWIEYGKQAVLCSCMVKISMDVFVRKFQPERYKLWK AGKDNTVIDHTLPTPEAAEFL Description Functional site 1) chain A residue 188 type sequence H description binding site for residue ZN A 401 source : AC1 2) chain A residue 190 type sequence E description binding site for residue ZN A 401 source : AC1 3) chain A residue 276 type sequence H description binding site for residue ZN A 401 source : AC1 4) chain A residue 234 type sequence C description binding site for residue ZN A 402 source : AC2 5) chain A residue 240 type sequence H description binding site for residue ZN A 402 source : AC2 6) chain A residue 306 type sequence C description binding site for residue ZN A 402 source : AC2 7) chain A residue 308 type sequence C description binding site for residue ZN A 402 source : AC2 8) chain A residue 132 type sequence Y description binding site for residue FQH A 403 source : AC3 9) chain A residue 177 type sequence Y description binding site for residue FQH A 403 source : AC3 10) chain A residue 185 type sequence F description binding site for residue FQH A 403 source : AC3 11) chain A residue 188 type sequence H description binding site for residue FQH A 403 source : AC3 12) chain A residue 190 type sequence E description binding site for residue FQH A 403 source : AC3 13) chain A residue 191 type sequence D description binding site for residue FQH A 403 source : AC3 14) chain A residue 206 type sequence K description binding site for residue FQH A 403 source : AC3 15) chain A residue 208 type sequence W description binding site for residue FQH A 403 source : AC3 16) chain A residue 276 type sequence H description binding site for residue FQH A 403 source : AC3 17) chain A residue 75 type sequence V description binding site for residue GOL A 404 source : AC4 18) chain A residue 76 type sequence T description binding site for residue GOL A 404 source : AC4 19) chain A residue 77 type sequence G description binding site for residue GOL A 404 source : AC4 20) chain A residue 126 type sequence T description binding site for residue GOL A 404 source : AC4 21) chain A residue 127 type sequence F description binding site for residue GOL A 404 source : AC4 22) chain C residue 75 type sequence V description binding site for residue GOL A 404 source : AC4 23) chain C residue 76 type sequence T description binding site for residue GOL A 404 source : AC4 24) chain C residue 77 type sequence G description binding site for residue GOL A 404 source : AC4 25) chain C residue 126 type sequence T description binding site for residue GOL A 404 source : AC4 26) chain C residue 127 type sequence F description binding site for residue GOL A 404 source : AC4 27) chain A residue 59 type sequence Y description binding site for residue CL A 405 source : AC5 28) chain B residue 188 type sequence H description binding site for residue ZN B 401 source : AC6 29) chain B residue 190 type sequence E description binding site for residue ZN B 401 source : AC6 30) chain B residue 276 type sequence H description binding site for residue ZN B 401 source : AC6 31) chain B residue 234 type sequence C description binding site for residue ZN B 402 source : AC7 32) chain B residue 240 type sequence H description binding site for residue ZN B 402 source : AC7 33) chain B residue 306 type sequence C description binding site for residue ZN B 402 source : AC7 34) chain B residue 308 type sequence C description binding site for residue ZN B 402 source : AC7 35) chain B residue 132 type sequence Y description binding site for residue FQH B 403 source : AC8 36) chain B residue 175 type sequence Y description binding site for residue FQH B 403 source : AC8 37) chain B residue 177 type sequence Y description binding site for residue FQH B 403 source : AC8 38) chain B residue 185 type sequence F description binding site for residue FQH B 403 source : AC8 39) chain B residue 188 type sequence H description binding site for residue FQH B 403 source : AC8 40) chain B residue 190 type sequence E description binding site for residue FQH B 403 source : AC8 41) chain B residue 206 type sequence K description binding site for residue FQH B 403 source : AC8 42) chain B residue 208 type sequence W description binding site for residue FQH B 403 source : AC8 43) chain B residue 276 type sequence H description binding site for residue FQH B 403 source : AC8 44) chain B residue 75 type sequence V description binding site for residue GOL B 404 source : AC9 45) chain B residue 76 type sequence T description binding site for residue GOL B 404 source : AC9 46) chain B residue 77 type sequence G description binding site for residue GOL B 404 source : AC9 47) chain B residue 126 type sequence T description binding site for residue GOL B 404 source : AC9 48) chain B residue 127 type sequence F description binding site for residue GOL B 404 source : AC9 49) chain C residue 188 type sequence H description binding site for residue ZN C 401 source : AD1 50) chain C residue 190 type sequence E description binding site for residue ZN C 401 source : AD1 51) chain C residue 276 type sequence H description binding site for residue ZN C 401 source : AD1 52) chain C residue 234 type sequence C description binding site for residue ZN C 402 source : AD2 53) chain C residue 240 type sequence H description binding site for residue ZN C 402 source : AD2 54) chain C residue 306 type sequence C description binding site for residue ZN C 402 source : AD2 55) chain C residue 308 type sequence C description binding site for residue ZN C 402 source : AD2 56) chain C residue 132 type sequence Y description binding site for residue FQH C 403 source : AD3 57) chain C residue 135 type sequence D description binding site for residue FQH C 403 source : AD3 58) chain C residue 169 type sequence E description binding site for residue FQH C 403 source : AD3 59) chain C residue 175 type sequence Y description binding site for residue FQH C 403 source : AD3 60) chain C residue 177 type sequence Y description binding site for residue FQH C 403 source : AD3 61) chain C residue 185 type sequence F description binding site for residue FQH C 403 source : AD3 62) chain C residue 188 type sequence H description binding site for residue FQH C 403 source : AD3 63) chain C residue 190 type sequence E description binding site for residue FQH C 403 source : AD3 64) chain C residue 191 type sequence D description binding site for residue FQH C 403 source : AD3 65) chain C residue 206 type sequence K description binding site for residue FQH C 403 source : AD3 66) chain C residue 208 type sequence W description binding site for residue FQH C 403 source : AD3 67) chain C residue 276 type sequence H description binding site for residue FQH C 403 source : AD3 68) chain C residue 12 type sequence A description binding site for residue DMS C 404 source : AD4 69) chain C residue 13 type sequence R description binding site for residue DMS C 404 source : AD4 70) chain C residue 257 type sequence F description binding site for residue DMS C 404 source : AD4 71) chain C residue 294 type sequence R description binding site for residue DMS C 405 source : AD5 72) chain C residue 324 type sequence F description binding site for residue DMS C 405 source : AD5 73) chain A residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 74) chain A residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 75) chain A residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 76) chain A residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 77) chain A residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 78) chain A residue 288 type catalytic sequence S description 370 source MCSA : MCSA1 79) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 80) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 81) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 82) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 83) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 84) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 85) chain C residue 170 type catalytic sequence G description 370 source MCSA : MCSA3 86) chain C residue 177 type catalytic sequence Y description 370 source MCSA : MCSA3 87) chain C residue 188 type catalytic sequence H description 370 source MCSA : MCSA3 88) chain C residue 190 type catalytic sequence E description 370 source MCSA : MCSA3 89) chain C residue 276 type catalytic sequence H description 370 source MCSA : MCSA3 90) chain C residue 288 type catalytic sequence S description 370 source MCSA : MCSA3 91) chain C residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 92) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 93) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 94) chain C residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 95) chain C residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 96) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 97) chain A residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 98) chain A residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 99) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 100) chain C residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 101) chain C residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 102) chain A residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 103) chain A residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 104) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 105) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 106) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 107) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 108) chain C residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 109) chain C residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 110) chain C residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 111) chain C residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 112) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 113) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 114) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 115) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 116) chain C residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 117) chain A residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 118) chain A residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 119) chain A residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 120) chain A residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 121) chain A residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 122) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 123) chain C residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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