eF-site ID 6h4o-B PDB Code 6h4o Chain B click to enlarge Title Crystal structure of human KDM4A in complex with compound 18a Classification OXIDOREDUCTASE Compound Lysine-specific demethylase 4A Source (KDM4A_HUMAN) Sequence B:  TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAK VVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYN IQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLT FNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEEGVNT PYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPP EHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKY GIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFAT RRWIEYGKQAVLCSCRMVKISMDVFVRKFQPERYKLWKAG KDNTVIDHTLPTPEAAEFL Description Functional site 1) chain B residue 188 type sequence H description binding site for residue ZN B 401 source : AC6 2) chain B residue 190 type sequence E description binding site for residue ZN B 401 source : AC6 3) chain B residue 276 type sequence H description binding site for residue ZN B 401 source : AC6 4) chain B residue 234 type sequence C description binding site for residue ZN B 402 source : AC7 5) chain B residue 240 type sequence H description binding site for residue ZN B 402 source : AC7 6) chain B residue 306 type sequence C description binding site for residue ZN B 402 source : AC7 7) chain B residue 308 type sequence C description binding site for residue ZN B 402 source : AC7 8) chain B residue 132 type sequence Y description binding site for residue FQH B 403 source : AC8 9) chain B residue 175 type sequence Y description binding site for residue FQH B 403 source : AC8 10) chain B residue 177 type sequence Y description binding site for residue FQH B 403 source : AC8 11) chain B residue 185 type sequence F description binding site for residue FQH B 403 source : AC8 12) chain B residue 188 type sequence H description binding site for residue FQH B 403 source : AC8 13) chain B residue 190 type sequence E description binding site for residue FQH B 403 source : AC8 14) chain B residue 206 type sequence K description binding site for residue FQH B 403 source : AC8 15) chain B residue 208 type sequence W description binding site for residue FQH B 403 source : AC8 16) chain B residue 276 type sequence H description binding site for residue FQH B 403 source : AC8 17) chain B residue 75 type sequence V description binding site for residue GOL B 404 source : AC9 18) chain B residue 76 type sequence T description binding site for residue GOL B 404 source : AC9 19) chain B residue 77 type sequence G description binding site for residue GOL B 404 source : AC9 20) chain B residue 126 type sequence T description binding site for residue GOL B 404 source : AC9 21) chain B residue 127 type sequence F description binding site for residue GOL B 404 source : AC9 22) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 29) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 30) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 31) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 32) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 33) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 34) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 35) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 36) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 37) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 38) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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