eF-site ID 6h4o-A
PDB Code 6h4o
Chain A

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Title Crystal structure of human KDM4A in complex with compound 18a
Classification OXIDOREDUCTASE
Compound Lysine-specific demethylase 4A
Source (KDM4A_HUMAN)
Sequence A:  LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKV
VPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNI
QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTF
NPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPY
LYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEH
GKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGI
PFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRR
WIEYGKQAVLCSCRKMVKISMDVFVRKFQPERYKLWKAGK
DNTVIDHTLPTPEAAEFL
Description


Functional site

1) chain A
residue 188
type
sequence H
description binding site for residue ZN A 401
source : AC1

2) chain A
residue 190
type
sequence E
description binding site for residue ZN A 401
source : AC1

3) chain A
residue 276
type
sequence H
description binding site for residue ZN A 401
source : AC1

4) chain A
residue 234
type
sequence C
description binding site for residue ZN A 402
source : AC2

5) chain A
residue 240
type
sequence H
description binding site for residue ZN A 402
source : AC2

6) chain A
residue 306
type
sequence C
description binding site for residue ZN A 402
source : AC2

7) chain A
residue 308
type
sequence C
description binding site for residue ZN A 402
source : AC2

8) chain A
residue 132
type
sequence Y
description binding site for residue FQH A 403
source : AC3

9) chain A
residue 177
type
sequence Y
description binding site for residue FQH A 403
source : AC3

10) chain A
residue 185
type
sequence F
description binding site for residue FQH A 403
source : AC3

11) chain A
residue 188
type
sequence H
description binding site for residue FQH A 403
source : AC3

12) chain A
residue 190
type
sequence E
description binding site for residue FQH A 403
source : AC3

13) chain A
residue 191
type
sequence D
description binding site for residue FQH A 403
source : AC3

14) chain A
residue 206
type
sequence K
description binding site for residue FQH A 403
source : AC3

15) chain A
residue 208
type
sequence W
description binding site for residue FQH A 403
source : AC3

16) chain A
residue 276
type
sequence H
description binding site for residue FQH A 403
source : AC3

17) chain A
residue 75
type
sequence V
description binding site for residue GOL A 404
source : AC4

18) chain A
residue 76
type
sequence T
description binding site for residue GOL A 404
source : AC4

19) chain A
residue 77
type
sequence G
description binding site for residue GOL A 404
source : AC4

20) chain A
residue 126
type
sequence T
description binding site for residue GOL A 404
source : AC4

21) chain A
residue 127
type
sequence F
description binding site for residue GOL A 404
source : AC4

22) chain A
residue 59
type
sequence Y
description binding site for residue CL A 405
source : AC5

23) chain A
residue 170
type catalytic
sequence G
description 370
source MCSA : MCSA1

24) chain A
residue 177
type catalytic
sequence Y
description 370
source MCSA : MCSA1

25) chain A
residue 188
type catalytic
sequence H
description 370
source MCSA : MCSA1

26) chain A
residue 190
type catalytic
sequence E
description 370
source MCSA : MCSA1

27) chain A
residue 276
type catalytic
sequence H
description 370
source MCSA : MCSA1

28) chain A
residue 288
type catalytic
sequence S
description 370
source MCSA : MCSA1

29) chain A
residue 132
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:16677698
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 198
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:16677698
source Swiss-Prot : SWS_FT_FI1

31) chain A
residue 206
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:16677698
source Swiss-Prot : SWS_FT_FI1

32) chain A
residue 188
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168
source Swiss-Prot : SWS_FT_FI2

33) chain A
residue 276
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168
source Swiss-Prot : SWS_FT_FI2

34) chain A
residue 190
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168
source Swiss-Prot : SWS_FT_FI3

35) chain A
residue 234
type BINDING
sequence C
description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I
source Swiss-Prot : SWS_FT_FI4

36) chain A
residue 240
type BINDING
sequence H
description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I
source Swiss-Prot : SWS_FT_FI4

37) chain A
residue 306
type BINDING
sequence C
description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I
source Swiss-Prot : SWS_FT_FI4

38) chain A
residue 308
type BINDING
sequence C
description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I
source Swiss-Prot : SWS_FT_FI4

39) chain A
residue 241
type BINDING
sequence K
description BINDING => ECO:0000250|UniProtKB:B2RXH2
source Swiss-Prot : SWS_FT_FI5


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