eF-site ID 6h4o-A PDB Code 6h4o Chain A click to enlarge Title Crystal structure of human KDM4A in complex with compound 18a Classification OXIDOREDUCTASE Compound Lysine-specific demethylase 4A Source (KDM4A_HUMAN) Sequence A:  LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKV VPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNI QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTF NPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPY LYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEH GKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGI PFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRR WIEYGKQAVLCSCRKMVKISMDVFVRKFQPERYKLWKAGK DNTVIDHTLPTPEAAEFL Description Functional site 1) chain A residue 188 type sequence H description binding site for residue ZN A 401 source : AC1 2) chain A residue 190 type sequence E description binding site for residue ZN A 401 source : AC1 3) chain A residue 276 type sequence H description binding site for residue ZN A 401 source : AC1 4) chain A residue 234 type sequence C description binding site for residue ZN A 402 source : AC2 5) chain A residue 240 type sequence H description binding site for residue ZN A 402 source : AC2 6) chain A residue 306 type sequence C description binding site for residue ZN A 402 source : AC2 7) chain A residue 308 type sequence C description binding site for residue ZN A 402 source : AC2 8) chain A residue 132 type sequence Y description binding site for residue FQH A 403 source : AC3 9) chain A residue 177 type sequence Y description binding site for residue FQH A 403 source : AC3 10) chain A residue 185 type sequence F description binding site for residue FQH A 403 source : AC3 11) chain A residue 188 type sequence H description binding site for residue FQH A 403 source : AC3 12) chain A residue 190 type sequence E description binding site for residue FQH A 403 source : AC3 13) chain A residue 191 type sequence D description binding site for residue FQH A 403 source : AC3 14) chain A residue 206 type sequence K description binding site for residue FQH A 403 source : AC3 15) chain A residue 208 type sequence W description binding site for residue FQH A 403 source : AC3 16) chain A residue 276 type sequence H description binding site for residue FQH A 403 source : AC3 17) chain A residue 75 type sequence V description binding site for residue GOL A 404 source : AC4 18) chain A residue 76 type sequence T description binding site for residue GOL A 404 source : AC4 19) chain A residue 77 type sequence G description binding site for residue GOL A 404 source : AC4 20) chain A residue 126 type sequence T description binding site for residue GOL A 404 source : AC4 21) chain A residue 127 type sequence F description binding site for residue GOL A 404 source : AC4 22) chain A residue 59 type sequence Y description binding site for residue CL A 405 source : AC5 23) chain A residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 24) chain A residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 25) chain A residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 26) chain A residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 27) chain A residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 28) chain A residue 288 type catalytic sequence S description 370 source MCSA : MCSA1 29) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 35) chain A residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 36) chain A residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 37) chain A residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 38) chain A residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 39) chain A residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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