eF-site ID 6h4g-A PDB Code 6h4g Chain A click to enlarge Title Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site Classification SIGNALING PROTEIN Compound Protein kinase A regulatory subunit Source (Q385V6_TRYB2) Sequence A:  AKSYVAPYFEKSEDETALILKLLTYNVLFSFLDSRDLMTV AGAMWRVEFKQDDCIMEAGQTTCDKLYIIQDGKADIIKEG QKVYLKVEGTAVGELALMYQTPRAATVKVCTPELIAWALD RDTYRHLVMGSAIRRRETYIQFLTNIPFLSGLDNYEKLQL ADALSSDEFEPGDYIIRYGEEGEWLYIILEGSVDVVGRDD DGNEKHVWEFGKGDHVGELEFLNNHANVADVVAKTHVVTA KLNRRHFEMCLGPVIDVLKRTSQQPNYEYYQSKL Description Functional site 1) chain A residue 271 type sequence M description binding site for residue CMP A 501 source : AC1 2) chain A residue 291 type sequence I description binding site for residue CMP A 501 source : AC1 3) chain A residue 299 type sequence Y description binding site for residue CMP A 501 source : AC1 4) chain A residue 307 type sequence V description binding site for residue CMP A 501 source : AC1 5) chain A residue 308 type sequence G description binding site for residue CMP A 501 source : AC1 6) chain A residue 309 type sequence E description binding site for residue CMP A 501 source : AC1 7) chain A residue 310 type sequence L description binding site for residue CMP A 501 source : AC1 8) chain A residue 311 type sequence A description binding site for residue CMP A 501 source : AC1 9) chain A residue 318 type sequence R description binding site for residue CMP A 501 source : AC1 10) chain A residue 319 type sequence A description binding site for residue CMP A 501 source : AC1 11) chain A residue 320 type sequence A description binding site for residue CMP A 501 source : AC1 12) chain A residue 370 type sequence Y description binding site for residue CMP A 501 source : AC1 13) chain A residue 410 type sequence V description binding site for residue NOS A 502 source : AC2 14) chain A residue 422 type sequence V description binding site for residue NOS A 502 source : AC2 15) chain A residue 431 type sequence V description binding site for residue NOS A 502 source : AC2 16) chain A residue 432 type sequence G description binding site for residue NOS A 502 source : AC2 17) chain A residue 434 type sequence L description binding site for residue NOS A 502 source : AC2 18) chain A residue 435 type sequence E description binding site for residue NOS A 502 source : AC2 19) chain A residue 443 type sequence V description binding site for residue NOS A 502 source : AC2 20) chain A residue 444 type sequence A description binding site for residue NOS A 502 source : AC2 21) chain A residue 481 type sequence N description binding site for residue NOS A 502 source : AC2 22) chain A residue 482 type sequence Y description binding site for residue NOS A 502 source : AC2 23) chain A residue 484 type sequence Y description binding site for residue NOS A 502 source : AC2 24) chain A residue 485 type sequence Y description binding site for residue NOS A 502 source : AC2 25) chain A residue 390-406 type prosite sequence IIRYGEEGEWLYIILEG description CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrYGEeGEwLYIIleG source prosite : PS00888 26) chain A residue 307-324 type prosite sequence VGELALMYQTPRAATVKV description CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. VGElALmyqtp......RAAtVkV source prosite : PS00889

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