eF-site ID 6h3q-A PDB Code 6h3q Chain A click to enlarge Title Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide Classification LYASE Compound Carbonic anhydrase 2 Source (CAH2_HUMAN) Sequence A:  HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPS LKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGP LDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHW NTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVL DSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLL ECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDN WRPAQPLKNRQIKASFK Description (1)  Carbonic anhydrase 2 (E.C.4.2.1.1) Functional site 1) chain A residue 94 type ligand sequence H description binding site for residue ZN A 301 source : AC1 2) chain A residue 96 type ligand sequence H description binding site for residue ZN A 301 source : AC1 3) chain A residue 119 type ligand sequence H description binding site for residue ZN A 301 source : AC1 4) chain A residue 94 type ligand sequence H description binding site for residue FMH A 302 source : AC2 5) chain A residue 96 type ligand sequence H description binding site for residue FMH A 302 source : AC2 6) chain A residue 119 type ligand sequence H description binding site for residue FMH A 302 source : AC2 7) chain A residue 131 type ligand sequence F description binding site for residue FMH A 302 source : AC2 8) chain A residue 198 type ligand sequence L description binding site for residue FMH A 302 source : AC2 9) chain A residue 199 type ligand sequence T description binding site for residue FMH A 302 source : AC2 10) chain A residue 200 type ligand sequence T description binding site for residue FMH A 302 source : AC2 11) chain A residue 209 type ligand sequence W description binding site for residue FMH A 302 source : AC2 12) chain A residue 92 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence Q description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 13) chain A residue 94 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence H description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 14) chain A residue 96 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence H description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 15) chain A residue 106 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence E description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 16) chain A residue 119 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence H description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 17) chain A residue 121 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence V description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 18) chain A residue 131 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence F description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 19) chain A residue 143 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence V description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 20) chain A residue 197-202 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence SLTTPP description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302 21) chain A residue 209 type binding ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide sequence W description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site source pdb_hetatom : FMH_6h3q_A_302

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