eF-site ID 6h3q-A
PDB Code 6h3q
Chain A

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Title Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide
Classification LYASE
Compound Carbonic anhydrase 2
Source (CAH2_HUMAN)
Sequence A:  HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPS
LKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGP
LDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHW
NTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVL
DSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLL
ECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDN
WRPAQPLKNRQIKASFK
Description (1)  Carbonic anhydrase 2 (E.C.4.2.1.1)


Functional site

1) chain A
residue 94
type
ligand
sequence H
description binding site for residue ZN A 301
source : AC1

2) chain A
residue 96
type
ligand
sequence H
description binding site for residue ZN A 301
source : AC1

3) chain A
residue 119
type
ligand
sequence H
description binding site for residue ZN A 301
source : AC1

4) chain A
residue 94
type
ligand
sequence H
description binding site for residue FMH A 302
source : AC2

5) chain A
residue 96
type
ligand
sequence H
description binding site for residue FMH A 302
source : AC2

6) chain A
residue 119
type
ligand
sequence H
description binding site for residue FMH A 302
source : AC2

7) chain A
residue 131
type
ligand
sequence F
description binding site for residue FMH A 302
source : AC2

8) chain A
residue 198
type
ligand
sequence L
description binding site for residue FMH A 302
source : AC2

9) chain A
residue 199
type
ligand
sequence T
description binding site for residue FMH A 302
source : AC2

10) chain A
residue 200
type
ligand
sequence T
description binding site for residue FMH A 302
source : AC2

11) chain A
residue 209
type
ligand
sequence W
description binding site for residue FMH A 302
source : AC2

12) chain A
residue 92
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence Q
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

13) chain A
residue 94
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence H
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

14) chain A
residue 96
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence H
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

15) chain A
residue 106
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence E
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

16) chain A
residue 119
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence H
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

17) chain A
residue 121
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence V
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

18) chain A
residue 131
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence F
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

19) chain A
residue 143
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence V
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

20) chain A
residue 197-202
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence SLTTPP
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302

21) chain A
residue 209
type binding
ligand FMH: 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide
sequence W
description 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide binding site
source pdb_hetatom : FMH_6h3q_A_302


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