eF-site ID 6h2v-ABCD PDB Code 6h2v Chain A, B, C, D click to enlarge Title Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 2.5A resolution Classification TRANSFERASE Compound Methyltransferase-like protein 5 Source (TR112_HUMAN) Sequence A:  KKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLY TIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFD IDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFD TVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSST REHVQKKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIE VDLIRFSFHH B:  MKLLTHNLLSSHGFPLRLQATEVRIXPVEFNPNFVARMIP KVEWSAFLEAADNLRLIQVPKGPVEGYEENEEFLRTMHHL LLEVEVIEGTLQCPESGRMFPISRGIPNMLL C:  KVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYT IHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDI DEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDT VIMNPPFGTDMAFLKTALEMARTAVYSLHKSSTREHVQKK AAEWKIKIDIIAELRYDLPAVDIEVDLIRFSFHH D:  MKLLTHNLLSSHFPLRLQATEVRIXPVEFNPNFVARMIPK VEWSAFLEAADNLRLIQVPKGPVEGYEENEEFLRTMHHLL LEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEET Description Functional site 1) chain A residue 19 type sequence F description binding site for residue SAM A 301 source : AC1 2) chain A residue 26 type sequence L description binding site for residue SAM A 301 source : AC1 3) chain A residue 27 type sequence E description binding site for residue SAM A 301 source : AC1 4) chain A residue 28 type sequence Q description binding site for residue SAM A 301 source : AC1 5) chain A residue 29 type sequence Y description binding site for residue SAM A 301 source : AC1 6) chain A residue 30 type sequence P description binding site for residue SAM A 301 source : AC1 7) chain A residue 31 type sequence T description binding site for residue SAM A 301 source : AC1 8) chain A residue 59 type sequence G description binding site for residue SAM A 301 source : AC1 9) chain A residue 60 type sequence C description binding site for residue SAM A 301 source : AC1 10) chain A residue 61 type sequence G description binding site for residue SAM A 301 source : AC1 11) chain A residue 62 type sequence C description binding site for residue SAM A 301 source : AC1 12) chain A residue 64 type sequence V description binding site for residue SAM A 301 source : AC1 13) chain A residue 81 type sequence D description binding site for residue SAM A 301 source : AC1 14) chain A residue 82 type sequence I description binding site for residue SAM A 301 source : AC1 15) chain A residue 107 type sequence C description binding site for residue SAM A 301 source : AC1 16) chain A residue 108 type sequence D description binding site for residue SAM A 301 source : AC1 17) chain A residue 109 type sequence V description binding site for residue SAM A 301 source : AC1 18) chain A residue 126 type sequence N description binding site for residue SAM A 301 source : AC1 19) chain A residue 128 type sequence P description binding site for residue SAM A 301 source : AC1 20) chain A residue 151 type sequence T description binding site for residue SO4 A 302 source : AC2 21) chain A residue 175 type sequence K description binding site for residue SO4 A 302 source : AC2 22) chain A residue 206 type sequence R description binding site for residue SO4 A 302 source : AC2 23) chain A residue 208 type sequence S description binding site for residue SO4 A 302 source : AC2 24) chain A residue 211 type sequence H description binding site for residue SO4 A 302 source : AC2 25) chain A residue 175 type sequence K description binding site for residue SO4 A 303 source : AC3 26) chain A residue 210 type sequence H description binding site for residue SO4 A 303 source : AC3 27) chain A residue 211 type sequence H description binding site for residue SO4 A 303 source : AC3 28) chain A residue 32 type sequence R description binding site for residue SO4 A 304 source : AC4 29) chain A residue 187 type sequence P description binding site for residue SO4 A 304 source : AC4 30) chain A residue 188 type sequence A description binding site for residue SO4 A 304 source : AC4 31) chain A residue 84 type sequence E description binding site for residue PEG B 201 source : AC5 32) chain A residue 106 type sequence Q description binding site for residue PEG B 201 source : AC5 33) chain B residue 108 type sequence P description binding site for residue PEG B 201 source : AC5 34) chain B residue 110 type sequence S description binding site for residue PEG B 201 source : AC5 35) chain B residue 113 type sequence I description binding site for residue PEG B 201 source : AC5 36) chain B residue 115 type sequence N description binding site for residue PEG B 201 source : AC5 37) chain B residue 90 type sequence E description binding site for residue EDO B 202 source : AC6 38) chain B residue 36 type sequence E description binding site for residue SO4 B 203 source : AC7 39) chain B residue 37 type sequence F description binding site for residue SO4 B 203 source : AC7 40) chain B residue 82 type sequence R description binding site for residue SO4 B 203 source : AC7 41) chain C residue 19 type sequence F description binding site for residue SAM C 301 source : AC8 42) chain C residue 26 type sequence L description binding site for residue SAM C 301 source : AC8 43) chain C residue 27 type sequence E description binding site for residue SAM C 301 source : AC8 44) chain C residue 28 type sequence Q description binding site for residue SAM C 301 source : AC8 45) chain C residue 29 type sequence Y description binding site for residue SAM C 301 source : AC8 46) chain C residue 30 type sequence P description binding site for residue SAM C 301 source : AC8 47) chain C residue 31 type sequence T description binding site for residue SAM C 301 source : AC8 48) chain C residue 59 type sequence G description binding site for residue SAM C 301 source : AC8 49) chain C residue 60 type sequence C description binding site for residue SAM C 301 source : AC8 50) chain C residue 61 type sequence G description binding site for residue SAM C 301 source : AC8 51) chain C residue 62 type sequence C description binding site for residue SAM C 301 source : AC8 52) chain C residue 64 type sequence V description binding site for residue SAM C 301 source : AC8 53) chain C residue 81 type sequence D description binding site for residue SAM C 301 source : AC8 54) chain C residue 82 type sequence I description binding site for residue SAM C 301 source : AC8 55) chain C residue 107 type sequence C description binding site for residue SAM C 301 source : AC8 56) chain C residue 108 type sequence D description binding site for residue SAM C 301 source : AC8 57) chain C residue 109 type sequence V description binding site for residue SAM C 301 source : AC8 58) chain C residue 126 type sequence N description binding site for residue SAM C 301 source : AC8 59) chain C residue 128 type sequence P description binding site for residue SAM C 301 source : AC8 60) chain A residue 132 type sequence K description binding site for residue PG0 C 302 source : AC9 61) chain A residue 133 type sequence N description binding site for residue PG0 C 302 source : AC9 62) chain C residue 32 type sequence R description binding site for residue PG0 C 302 source : AC9 63) chain C residue 33 type sequence P description binding site for residue PG0 C 302 source : AC9 64) chain C residue 34 type sequence H description binding site for residue PG0 C 302 source : AC9 65) chain C residue 151 type sequence T description binding site for residue SO4 C 303 source : AD1 66) chain C residue 206 type sequence R description binding site for residue SO4 C 303 source : AD1 67) chain C residue 208 type sequence S description binding site for residue SO4 C 303 source : AD1 68) chain C residue 211 type sequence H description binding site for residue SO4 C 303 source : AD1 69) chain C residue 175 type sequence K description binding site for residue SO4 C 304 source : AD2 70) chain C residue 210 type sequence H description binding site for residue SO4 C 304 source : AD2 71) chain C residue 211 type sequence H description binding site for residue SO4 C 304 source : AD2 72) chain C residue 91 type sequence N description binding site for residue EDO D 201 source : AD3 73) chain C residue 103 type sequence D description binding site for residue EDO D 201 source : AD3 74) chain C residue 104 type sequence M description binding site for residue EDO D 201 source : AD3 75) chain D residue 33 type sequence X description binding site for residue EDO D 201 source : AD3 76) chain D residue 92 type sequence E description binding site for residue EDO D 201 source : AD3 77) chain D residue 111 type sequence R description binding site for residue EDO D 201 source : AD3 78) chain D residue 112 type sequence G description binding site for residue EDO D 201 source : AD3 79) chain C residue 95 type sequence E description binding site for residue PG0 D 202 source : AD4 80) chain D residue 29 type sequence E description binding site for residue PG0 D 202 source : AD4 81) chain D residue 31 type sequence R description binding site for residue PG0 D 202 source : AD4 82) chain D residue 33 type sequence X description binding site for residue PG0 D 202 source : AD4 83) chain D residue 94 type sequence I description binding site for residue PG0 D 202 source : AD4 84) chain D residue 95 type sequence E description binding site for residue PG0 D 202 source : AD4 85) chain D residue 111 type sequence R description binding site for residue PG0 D 202 source : AD4 86) chain B residue 62 type sequence R description binding site for residue SO4 D 203 source : AD5 87) chain D residue 37 type sequence F description binding site for residue SO4 D 203 source : AD5 88) chain D residue 82 type sequence R description binding site for residue SO4 D 203 source : AD5 89) chain C residue 108 type MOD_RES sequence D description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 90) chain D residue 119 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 91) chain A residue 59 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 92) chain A residue 81 type MOD_RES sequence D description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 93) chain A residue 108 type MOD_RES sequence D description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 94) chain C residue 28 type MOD_RES sequence Q description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 95) chain C residue 31 type MOD_RES sequence T description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 96) chain C residue 59 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 97) chain C residue 81 type MOD_RES sequence D description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 98) chain A residue 64 type BINDING sequence V description BINDING => ECO:0000269|PubMed:31328227, ECO:0007744|PDB:6H2V source Swiss-Prot : SWS_FT_FI3 99) chain C residue 64 type BINDING sequence V description BINDING => ECO:0000269|PubMed:31328227, ECO:0007744|PDB:6H2V source Swiss-Prot : SWS_FT_FI3 100) chain A residue 123-129 type prosite sequence VIMNPPF description N6_MTASE N-6 Adenine-specific DNA methylases signature. VIMNPPF source prosite : PS00092

Display surface Download Links