eF-site ID 6h2v-A PDB Code 6h2v Chain A click to enlarge Title Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 2.5A resolution Classification TRANSFERASE Compound Methyltransferase-like protein 5 Source (TR112_HUMAN) Sequence A:  KKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLY TIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFD IDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFD TVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSST REHVQKKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIE VDLIRFSFHH Description Functional site 1) chain A residue 19 type sequence F description binding site for residue SAM A 301 source : AC1 2) chain A residue 26 type sequence L description binding site for residue SAM A 301 source : AC1 3) chain A residue 27 type sequence E description binding site for residue SAM A 301 source : AC1 4) chain A residue 28 type sequence Q description binding site for residue SAM A 301 source : AC1 5) chain A residue 29 type sequence Y description binding site for residue SAM A 301 source : AC1 6) chain A residue 30 type sequence P description binding site for residue SAM A 301 source : AC1 7) chain A residue 31 type sequence T description binding site for residue SAM A 301 source : AC1 8) chain A residue 59 type sequence G description binding site for residue SAM A 301 source : AC1 9) chain A residue 60 type sequence C description binding site for residue SAM A 301 source : AC1 10) chain A residue 61 type sequence G description binding site for residue SAM A 301 source : AC1 11) chain A residue 62 type sequence C description binding site for residue SAM A 301 source : AC1 12) chain A residue 64 type sequence V description binding site for residue SAM A 301 source : AC1 13) chain A residue 81 type sequence D description binding site for residue SAM A 301 source : AC1 14) chain A residue 82 type sequence I description binding site for residue SAM A 301 source : AC1 15) chain A residue 107 type sequence C description binding site for residue SAM A 301 source : AC1 16) chain A residue 108 type sequence D description binding site for residue SAM A 301 source : AC1 17) chain A residue 109 type sequence V description binding site for residue SAM A 301 source : AC1 18) chain A residue 126 type sequence N description binding site for residue SAM A 301 source : AC1 19) chain A residue 128 type sequence P description binding site for residue SAM A 301 source : AC1 20) chain A residue 151 type sequence T description binding site for residue SO4 A 302 source : AC2 21) chain A residue 175 type sequence K description binding site for residue SO4 A 302 source : AC2 22) chain A residue 206 type sequence R description binding site for residue SO4 A 302 source : AC2 23) chain A residue 208 type sequence S description binding site for residue SO4 A 302 source : AC2 24) chain A residue 211 type sequence H description binding site for residue SO4 A 302 source : AC2 25) chain A residue 175 type sequence K description binding site for residue SO4 A 303 source : AC3 26) chain A residue 210 type sequence H description binding site for residue SO4 A 303 source : AC3 27) chain A residue 211 type sequence H description binding site for residue SO4 A 303 source : AC3 28) chain A residue 32 type sequence R description binding site for residue SO4 A 304 source : AC4 29) chain A residue 187 type sequence P description binding site for residue SO4 A 304 source : AC4 30) chain A residue 188 type sequence A description binding site for residue SO4 A 304 source : AC4 31) chain A residue 84 type sequence E description binding site for residue PEG B 201 source : AC5 32) chain A residue 106 type sequence Q description binding site for residue PEG B 201 source : AC5 33) chain A residue 132 type sequence K description binding site for residue PG0 C 302 source : AC9 34) chain A residue 133 type sequence N description binding site for residue PG0 C 302 source : AC9 35) chain A residue 123-129 type prosite sequence VIMNPPF description N6_MTASE N-6 Adenine-specific DNA methylases signature. VIMNPPF source prosite : PS00092 36) chain A residue 59 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 81 type MOD_RES sequence D description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 108 type MOD_RES sequence D description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 64 type BINDING sequence V description BINDING => ECO:0000269|PubMed:31328227, ECO:0007744|PDB:6H2V source Swiss-Prot : SWS_FT_FI3

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