eF-site ID 6h23-N PDB Code 6h23 Chain N click to enlarge Title Crystal structure of the hClpP Y118A mutant with an activating small molecule Classification HYDROLASE Compound ATP-dependent Clp protease proteolytic subunit, mitochondrial Source (CLPP_HUMAN) Sequence N:  YDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNK KPIHMAINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAA SMGSLLLAAGTPGMRHSLPNSRIMIHQPSIAIQAEEIMKL KKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGIL DKVLVHPP Description (1)  ATP-dependent Clp protease proteolytic subunit, mitochondrial (E.C.3.4.21.92) Functional site 1) chain N residue 100 type sequence I description binding site for residue FJT H 301 source : AD2 2) chain N residue 101 type sequence A description binding site for residue FJT H 301 source : AD2 3) chain N residue 104 type sequence L description binding site for residue FJT H 301 source : AD2 4) chain N residue 105 type sequence F description binding site for residue FJT H 301 source : AD2 5) chain N residue 108 type sequence S description binding site for residue FJT H 301 source : AD2 6) chain N residue 138 type sequence Y description binding site for residue FJT H 301 source : AD2 7) chain N residue 79 type sequence L description binding site for residue FJT M 302 source : AD8 8) chain N residue 82 type sequence E description binding site for residue FJT M 302 source : AD8 9) chain N residue 84 type sequence I description binding site for residue FJT M 302 source : AD8 10) chain N residue 146 type sequence W description binding site for residue FJT M 302 source : AD8 11) chain N residue 148 type sequence V description binding site for residue FJT M 302 source : AD8 12) chain N residue 179 type sequence Q description binding site for residue EDO N 301 source : AD9 13) chain N residue 198 type sequence I description binding site for residue EDO N 301 source : AD9 14) chain N residue 202 type sequence K description binding site for residue EDO N 301 source : AD9 15) chain N residue 153 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11923310 source Swiss-Prot : SWS_FT_FI1 16) chain N residue 178 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 17) chain N residue 200 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:O88696 source Swiss-Prot : SWS_FT_FI3 18) chain N residue 211 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4

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