eF-site ID 6h23-H PDB Code 6h23 Chain H click to enlarge Title Crystal structure of the hClpP Y118A mutant with an activating small molecule Classification HYDROLASE Compound ATP-dependent Clp protease proteolytic subunit, mitochondrial Source (CLPP_HUMAN) Sequence H:  YDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNK KPIHMAINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAA SMGSLLLAAGTPGMRHSLPNSRIMIHQPDIAIQAEEIMKL KKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGIL DKVLVHP Description (1)  ATP-dependent Clp protease proteolytic subunit, mitochondrial (E.C.3.4.21.92) Functional site 1) chain H residue 179 type sequence Q description binding site for residue EDO A 302 source : AC2 2) chain H residue 202 type sequence K description binding site for residue EDO A 302 source : AC2 3) chain H residue 78 type sequence R description binding site for residue FJT H 301 source : AD2 4) chain H residue 79 type sequence L description binding site for residue FJT H 301 source : AD2 5) chain H residue 82 type sequence E description binding site for residue FJT H 301 source : AD2 6) chain H residue 146 type sequence W description binding site for residue FJT H 301 source : AD2 7) chain H residue 148 type sequence V description binding site for residue FJT H 301 source : AD2 8) chain H residue 100 type sequence I description binding site for residue FJT H 302 source : AD3 9) chain H residue 101 type sequence A description binding site for residue FJT H 302 source : AD3 10) chain H residue 104 type sequence L description binding site for residue FJT H 302 source : AD3 11) chain H residue 105 type sequence F description binding site for residue FJT H 302 source : AD3 12) chain H residue 107 type sequence Q description binding site for residue FJT H 302 source : AD3 13) chain H residue 108 type sequence S description binding site for residue FJT H 302 source : AD3 14) chain H residue 138 type sequence Y description binding site for residue FJT H 302 source : AD3 15) chain H residue 153 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11923310 source Swiss-Prot : SWS_FT_FI1 16) chain H residue 178 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 17) chain H residue 200 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:O88696 source Swiss-Prot : SWS_FT_FI3 18) chain H residue 211 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4

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