eF-site ID 6h23-E PDB Code 6h23 Chain E click to enlarge Title Crystal structure of the hClpP Y118A mutant with an activating small molecule Classification HYDROLASE Compound ATP-dependent Clp protease proteolytic subunit, mitochondrial Source (CLPP_HUMAN) Sequence E:  YDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNK KPIHMAINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAA SMGSLLLAAGTPGMRHSLPNSRIMIHQPIAIQAEEIMKLK KQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILD KVLVHP Description (1)  ATP-dependent Clp protease proteolytic subunit, mitochondrial (E.C.3.4.21.92) Functional site 1) chain E residue 78 type sequence R description binding site for residue FJT D 302 source : AC5 2) chain E residue 79 type sequence L description binding site for residue FJT D 302 source : AC5 3) chain E residue 82 type sequence E description binding site for residue FJT D 302 source : AC5 4) chain E residue 146 type sequence W description binding site for residue FJT D 302 source : AC5 5) chain E residue 100 type sequence I description binding site for residue FJT E 301 source : AC6 6) chain E residue 101 type sequence A description binding site for residue FJT E 301 source : AC6 7) chain E residue 104 type sequence L description binding site for residue FJT E 301 source : AC6 8) chain E residue 105 type sequence F description binding site for residue FJT E 301 source : AC6 9) chain E residue 108 type sequence S description binding site for residue FJT E 301 source : AC6 10) chain E residue 138 type sequence Y description binding site for residue FJT E 301 source : AC6 11) chain E residue 202 type sequence K description binding site for residue EDO E 302 source : AC7 12) chain E residue 153 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11923310 source Swiss-Prot : SWS_FT_FI1 13) chain E residue 178 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 14) chain E residue 200 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:O88696 source Swiss-Prot : SWS_FT_FI3 15) chain E residue 211 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4

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