eF-site ID 6h23-A PDB Code 6h23 Chain A click to enlarge Title Crystal structure of the hClpP Y118A mutant with an activating small molecule Classification HYDROLASE Compound ATP-dependent Clp protease proteolytic subunit, mitochondrial Source (CLPP_HUMAN) Sequence A:  DIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKK PIHMAINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAAS MGSLLLAAGTPGMRHSLPNSRIMIHQPIAIQAEEIMKLKK QLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDK VLVHP Description (1)  ATP-dependent Clp protease proteolytic subunit, mitochondrial (E.C.3.4.21.92) Functional site 1) chain A residue 101 type sequence A description binding site for residue FJT A 301 source : AC1 2) chain A residue 104 type sequence L description binding site for residue FJT A 301 source : AC1 3) chain A residue 105 type sequence F description binding site for residue FJT A 301 source : AC1 4) chain A residue 108 type sequence S description binding site for residue FJT A 301 source : AC1 5) chain A residue 138 type sequence Y description binding site for residue FJT A 301 source : AC1 6) chain A residue 194 type sequence Q description binding site for residue EDO A 302 source : AC2 7) chain A residue 195 type sequence A description binding site for residue EDO A 302 source : AC2 8) chain A residue 79 type sequence L description binding site for residue FJT G 301 source : AD1 9) chain A residue 82 type sequence E description binding site for residue FJT G 301 source : AD1 10) chain A residue 84 type sequence I description binding site for residue FJT G 301 source : AD1 11) chain A residue 146 type sequence W description binding site for residue FJT G 301 source : AD1 12) chain A residue 153 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11923310 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 178 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 145-156 type prosite sequence TWCVGQAASMGS description CLP_PROTEASE_SER Endopeptidase Clp serine active site. TwcVGqAASMGS source prosite : PS00381 15) chain A residue 167-180 type prosite sequence RHSLPNSRIMIHQP description CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RhslPnsrIMIHQP source prosite : PS00382 16) chain A residue 200 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:O88696 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 211 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4

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