eF-site ID 6h0a-A PDB Code 6h0a Chain A click to enlarge Title Serum paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations Classification HYDROLASE Compound Serum Paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations Source (6H0A) Sequence A:  FDRQKSSFQTRFNVHREVTPVELPNCNLVKGIDNGSEDLE ILPNGLAFISSGGKYPGIMSFDPDKSGKILLMDLNEKEPA VSELEIIGNTLDISSFNPWGISTFIDDDNTVYLLVVNRPG SSSTVEVFKFQEEEKSLLHLKTIRHKLLPSVNDIVAVGPE HFYATNDHYFIDPYLKSWEMHLGLAWSFVTYYSPNDVRVV AEGFDSANGINISPDGKYVYIAELLAHKIHVYEKHANWTL TPLRVLSFDTLVDNISVDPVTGDLWVGCHPNGMRIFFYDA ENPPGSEVLRIQDILSEEPKVTVVYAENGTVLQGSSVAAV YKGKLLIGTVFHKALYCDL Description (1)  Serum Paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations Functional site 1) chain A residue 54 type sequence D description binding site for residue CA A 401 source : AC1 2) chain A residue 117 type sequence I description binding site for residue CA A 401 source : AC1 3) chain A residue 169 type sequence D description binding site for residue CA A 401 source : AC1 4) chain A residue 224 type sequence N description binding site for residue CA A 402 source : AC2 5) chain A residue 269 type sequence D description binding site for residue CA A 402 source : AC2 6) chain A residue 39 type sequence L description binding site for residue B3P A 403 source : AC3 7) chain A residue 40 type sequence P description binding site for residue B3P A 403 source : AC3 8) chain A residue 41 type sequence N description binding site for residue B3P A 403 source : AC3 9) chain A residue 42 type sequence C description binding site for residue B3P A 403 source : AC3 10) chain A residue 185 type sequence Y description binding site for residue LMT A 404 source : AC4 11) chain A residue 218 type sequence E description binding site for residue LMT A 404 source : AC4 12) chain A residue 219 type sequence G description binding site for residue LMT A 404 source : AC4 13) chain A residue 157 type sequence K description binding site for residue PEG A 405 source : AC5 14) chain A residue 158 type sequence T description binding site for residue PEG A 405 source : AC5 15) chain A residue 306 type sequence R description binding site for residue PEG A 405 source : AC5 16) chain A residue 320 type sequence V description binding site for residue PEG A 405 source : AC5 17) chain A residue 287 type sequence N description binding site for residue BR A 406 source : AC6 18) chain A residue 290 type sequence R description binding site for residue BR A 406 source : AC6 19) chain A residue 301 type sequence G description binding site for residue BR A 406 source : AC6

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