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eF-site ID
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6h04-L |
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PDB Code
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6h04 |
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Chain
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L |
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click to enlarge
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Title
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Closed conformation of the Membrane Attack Complex |
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Classification
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IMMUNE SYSTEM |
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Compound
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Complement component C9 |
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Source
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ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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L: |
SHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRC
TDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLR
CNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGY
GINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWN
VASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAA
ISLKFTPSLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFL
HVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEY
FAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELK
DIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVN
ITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDF
VNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLE
RAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFE
GIACEISKQKISEGLPALEFP
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Description
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(1) |
C9, Complement C5,Complement C5, Complement component C8 beta chain, Complement component C7, Complement component C8 gamma chain, Complement component C8 alpha chain, Complement component C6
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Functional site
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1)
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chain |
L |
| residue |
507-518 |
| type |
prosite |
| sequence |
CACPFKFEGIAC
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| description |
EGF_1 EGF-like domain signature 1. CqCrlGslGAaC
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| source |
prosite : PS00022
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2)
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chain |
L |
| residue |
314-325 |
| type |
prosite |
| sequence |
YFAFLETYGTHY
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| description |
MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YakfindYGTHY
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| source |
prosite : PS00279
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3)
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chain |
L |
| residue |
91-113 |
| type |
prosite |
| sequence |
CIKMRLRCNGDNDCGDFSDEDDC
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| description |
LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CLkrhlv.CNgdqDCldgsDEDd....C
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| source |
prosite : PS01209
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4)
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chain |
L |
| residue |
505-518 |
| type |
prosite |
| sequence |
CLCACPFKFEGIAC
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| description |
EGF_2 EGF-like domain signature 2. ClCacPFkfegia..C
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| source |
prosite : PS01186
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5)
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chain |
L |
| residue |
314-333 |
| type |
CARBOHYD |
| sequence |
YFAFLETYGTHYSSSGSLGG
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| description |
C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839
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| source |
Swiss-Prot : SWS_FT_FI1
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6)
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chain |
L |
| residue |
394 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
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| source |
Swiss-Prot : SWS_FT_FI6
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