|
|
eF-site ID
|
6h04-D |
|
PDB Code
|
6h04 |
|
Chain
|
D |
|
click to enlarge
|
|
|
Title
|
Closed conformation of the Membrane Attack Complex |
|
Classification
|
IMMUNE SYSTEM |
|
Compound
|
Complement component C9 |
|
Source
|
ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; |
|
|
Sequence
|
D: |
SSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQP
CVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLV
CNGDSDCDEDSADEDRCEDSERRPSCDIDKPPPNIELTGN
GYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGN
VLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKR
SFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQF
INNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTH
YLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGW
HFVVKFSSHGCKELENALKAASGTQNNVLRGEPFIRGAGF
ISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPL
YELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGG
LATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWS
CWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQ
CEDEELEHLRLLEPHCFCPSPPALKDGFVQDEGTMFPVGK
NVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVL
PVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC
GSSLKWSPEMKNARCVQKEN
|
|
|
Description
|
(1) |
C9, Complement C5,Complement C5, Complement component C8 beta chain, Complement component C7, Complement component C8 gamma chain, Complement component C8 alpha chain, Complement component C6
|
|
Functional site
|
|
|
1)
|
chain |
D |
| residue |
475-486 |
| type |
prosite |
| sequence |
CHCKPYTFGAAC
|
| description |
EGF_1 EGF-like domain signature 1. CqCrlGslGAaC
|
| source |
prosite : PS00022
|
|
|
2)
|
chain |
D |
| residue |
292-303 |
| type |
prosite |
| sequence |
YRRLIDQYGTHY
|
| description |
MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YakfindYGTHY
|
| source |
prosite : PS00279
|
|
|
3)
|
chain |
D |
| residue |
96-119 |
| type |
prosite |
| sequence |
CISKSLVCNGDSDCDEDSADEDRC
|
| description |
LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CLkrhlv.CNgdqDCldgsDEDd....C
|
| source |
prosite : PS01209
|
|
|
4)
|
chain |
D |
| residue |
509 |
| type |
CARBOHYD |
| sequence |
W
|
| description |
O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|