eF-site ID 6h04-B PDB Code 6h04 Chain B click to enlarge Title Closed conformation of the Membrane Attack Complex Classification IMMUNE SYSTEM Compound Complement component C9 Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence B:  FCDHYAWTQWTSCSKTCNSGTQSRHQIVVDKYYQENFCEQ ICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKV RSCTAPLVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIAR KLECNGENDCGDNSDERDCGRTKAVCTRKYNPIPSVQLMG NGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPA NLENVGFEVQTATDFYKDLTSLGHNENQQGSFSSQGGSSF SVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKV MKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFD DFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHC VRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEK SISLIRSEYGAALAWEKGSSGLEEKTFSEWLESVKENPAV IDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQ CAPCPNNGRPTLSGTECLCVCQSGTYGENCGQWGCWSSWS TCDATYKRSRTRECNCEGEKRQEEDCTFSIMENNGQPCIN DDEEMKEGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTG FETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTI TPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPI SNSLTCEK Description (1)  C9, Complement C5,Complement C5, Complement component C8 beta chain, Complement component C7, Complement component C8 gamma chain, Complement component C8 alpha chain, Complement component C6 Functional site 1) chain B residue 541-552 type prosite sequence CVCQSGTYGENC description EGF_1 EGF-like domain signature 1. CaCpfKfeGIaC source prosite : PS00022 2) chain B residue 151-173 type prosite sequence CIARKLECNGENDCGDNSDERDC description LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIkmrlr.CNgdnDCgdfsDEDd....C source prosite : PS01209 3) chain B residue 29 type CARBOHYD sequence W description C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 32 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 90 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 568 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 571 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 574 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 38 type CARBOHYD sequence T description O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 392 type CARBOHYD sequence T description O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 324 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:22267737 source Swiss-Prot : SWS_FT_FI4 12) chain B residue 354-365 type prosite sequence YSRIFDDFGTHY description MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YfafletYGTHY source prosite : PS00279

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