eF-site ID 6h03-G
PDB Code 6h03
Chain G

click to enlarge
Title OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Classification IMMUNE SYSTEM
Compound Complement C5,Complement C5
Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence G:  SHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRC
TDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLR
CNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGY
GINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWN
VASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAA
ISLKFTPSLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFL
HVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEY
FAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELK
DIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVN
ITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDF
VNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLE
RAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFE
GIACEISKQKISEGLPALEFP
Description (1)  COMPLEMENT C5,COMPLEMENT C5, COMPLEMENT COMPONENT C6, COMPLEMENT COMPONENT C8 BETA CHAIN, COMPLEMENT COMPONENT C7, COMPLEMENT COMPONENT C8 GAMMA CHAIN, COMPLEMENT COMPONENT C8 ALPHA CHAIN, COMPLEMENT COMPONENT C9


Functional site

1) chain G
residue 507-518
type prosite
sequence CACPFKFEGIAC
description EGF_1 EGF-like domain signature 1. CvCqsGtyGEnC
source prosite : PS00022

2) chain G
residue 314-325
type prosite
sequence YFAFLETYGTHY
description MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY
source prosite : PS00279

3) chain G
residue 505-518
type prosite
sequence CLCACPFKFEGIAC
description EGF_2 EGF-like domain signature 2. CvCkmPYecgpsldvC
source prosite : PS01186

4) chain G
residue 91-113
type prosite
sequence CIKMRLRCNGDNDCGDFSDEDDC
description LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C
source prosite : PS01209

5) chain G
residue 293-309
type TRANSMEM
sequence VLTTTFVDDIKALPTTY
description Beta stranded => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

6) chain G
residue 314-333
type TRANSMEM
sequence YFAFLETYGTHYSSSGSLGG
description Beta stranded => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

7) chain G
residue 244
type SITE
sequence H
description Cleavage; by thrombin
source Swiss-Prot : SWS_FT_FI2

8) chain G
residue 27
type CARBOHYD
sequence W
description C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839
source Swiss-Prot : SWS_FT_FI3

9) chain G
residue 30
type CARBOHYD
sequence W
description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839
source Swiss-Prot : SWS_FT_FI4

10) chain G
residue 256
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
source Swiss-Prot : SWS_FT_FI5

11) chain G
residue 394
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
source Swiss-Prot : SWS_FT_FI6


Display surface

Download
Links