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eF-site ID
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6h03-G |
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PDB Code
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6h03 |
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Chain
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G |
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click to enlarge
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Title
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OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX |
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Classification
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IMMUNE SYSTEM |
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Compound
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Complement C5,Complement C5 |
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Source
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ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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G: |
SHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRC
TDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLR
CNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGY
GINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWN
VASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAA
ISLKFTPSLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFL
HVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEY
FAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELK
DIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVN
ITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDF
VNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLE
RAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFE
GIACEISKQKISEGLPALEFP
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Description
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(1) |
COMPLEMENT C5,COMPLEMENT C5, COMPLEMENT COMPONENT C6, COMPLEMENT COMPONENT C8 BETA CHAIN, COMPLEMENT COMPONENT C7, COMPLEMENT COMPONENT C8 GAMMA CHAIN, COMPLEMENT COMPONENT C8 ALPHA CHAIN, COMPLEMENT COMPONENT C9
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Functional site
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1)
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chain |
G |
| residue |
507-518 |
| type |
prosite |
| sequence |
CACPFKFEGIAC
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| description |
EGF_1 EGF-like domain signature 1. CvCqsGtyGEnC
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| source |
prosite : PS00022
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2)
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chain |
G |
| residue |
314-325 |
| type |
prosite |
| sequence |
YFAFLETYGTHY
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| description |
MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY
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| source |
prosite : PS00279
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3)
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chain |
G |
| residue |
505-518 |
| type |
prosite |
| sequence |
CLCACPFKFEGIAC
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| description |
EGF_2 EGF-like domain signature 2. CvCkmPYecgpsldvC
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| source |
prosite : PS01186
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4)
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chain |
G |
| residue |
91-113 |
| type |
prosite |
| sequence |
CIKMRLRCNGDNDCGDFSDEDDC
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| description |
LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C
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| source |
prosite : PS01209
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5)
|
chain |
G |
| residue |
293-309 |
| type |
TRANSMEM |
| sequence |
VLTTTFVDDIKALPTTY
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| description |
Beta stranded => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI1
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6)
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chain |
G |
| residue |
314-333 |
| type |
TRANSMEM |
| sequence |
YFAFLETYGTHYSSSGSLGG
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| description |
Beta stranded => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI1
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7)
|
chain |
G |
| residue |
244 |
| type |
SITE |
| sequence |
H
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| description |
Cleavage; by thrombin
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| source |
Swiss-Prot : SWS_FT_FI2
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8)
|
chain |
G |
| residue |
27 |
| type |
CARBOHYD |
| sequence |
W
|
| description |
C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839
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| source |
Swiss-Prot : SWS_FT_FI3
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9)
|
chain |
G |
| residue |
30 |
| type |
CARBOHYD |
| sequence |
W
|
| description |
C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839
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| source |
Swiss-Prot : SWS_FT_FI4
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10)
|
chain |
G |
| residue |
256 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
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| source |
Swiss-Prot : SWS_FT_FI5
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11)
|
chain |
G |
| residue |
394 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
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| source |
Swiss-Prot : SWS_FT_FI6
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