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eF-site ID
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6h03-C |
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PDB Code
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6h03 |
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Chain
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C |
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click to enlarge
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Title
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OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX |
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Classification
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IMMUNE SYSTEM |
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Compound
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Complement C5,Complement C5 |
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Source
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ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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C: |
PIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCN
FSDKEVEDCVTNRPCRSQVRCEGFVCAQTGRCVNRRLLCN
GDNDCGDQSDEANCRRIYKKCQHEMDQYWGIGSLASGINL
FTNSFEGPVLDHRYYCSPHYILNTRFRKPYNVESYTPQTQ
GKYEFILKEYESYSDFERNVTEKMASKSGFSFGFKIPGIF
ELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHY
KLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRDFGTHY
ITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFK
IGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMVEDLV
VLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIK
VKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCH
CAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPI
DGKWNCWSNWSSCSGRRKTRQRQSGPASETLDC
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Description
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(1) |
COMPLEMENT C5,COMPLEMENT C5, COMPLEMENT COMPONENT C6, COMPLEMENT COMPONENT C8 BETA CHAIN, COMPLEMENT COMPONENT C7, COMPLEMENT COMPONENT C8 GAMMA CHAIN, COMPLEMENT COMPONENT C8 ALPHA CHAIN, COMPLEMENT COMPONENT C9
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Functional site
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1)
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chain |
C |
| residue |
469-480 |
| type |
prosite |
| sequence |
CICPVGSQGLAC
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| description |
EGF_1 EGF-like domain signature 1. CqCrlGslGAaC
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| source |
prosite : PS00022
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2)
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chain |
C |
| residue |
79-101 |
| type |
prosite |
| sequence |
CVNRRLLCNGDNDCGDQSDEANC
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| description |
LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CLkrhlv.CNgdqDCldgsDEDd....C
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| source |
prosite : PS01209
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3)
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chain |
C |
| residue |
279-290 |
| type |
prosite |
| sequence |
YRDLFRDFGTHY
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| description |
MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YakfindYGTHY
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| source |
prosite : PS00279
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