|
eF-site ID
|
6h03-G |
PDB Code
|
6h03 |
Chain
|
G |
|
click to enlarge
|
|
Title
|
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX |
Classification
|
IMMUNE SYSTEM |
Compound
|
Complement C5,Complement C5 |
Source
|
ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; |
|
Sequence
|
G: |
SHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRC
TDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLR
CNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGY
GINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWN
VASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAA
ISLKFTPSLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFL
HVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEY
FAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELK
DIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVN
ITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDF
VNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLE
RAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFE
GIACEISKQKISEGLPALEFP
|
|
Description
|
(1) |
COMPLEMENT C5,COMPLEMENT C5, COMPLEMENT COMPONENT C6, COMPLEMENT COMPONENT C8 BETA CHAIN, COMPLEMENT COMPONENT C7, COMPLEMENT COMPONENT C8 GAMMA CHAIN, COMPLEMENT COMPONENT C8 ALPHA CHAIN, COMPLEMENT COMPONENT C9
|
|
Functional site
|
|
1)
|
chain |
G |
residue |
507-518 |
type |
prosite |
sequence |
CACPFKFEGIAC
|
description |
EGF_1 EGF-like domain signature 1. CvCqsGtyGEnC
|
source |
prosite : PS00022
|
|
2)
|
chain |
G |
residue |
314-325 |
type |
prosite |
sequence |
YFAFLETYGTHY
|
description |
MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY
|
source |
prosite : PS00279
|
|
3)
|
chain |
G |
residue |
505-518 |
type |
prosite |
sequence |
CLCACPFKFEGIAC
|
description |
EGF_2 EGF-like domain signature 2. CvCkmPYecgpsldvC
|
source |
prosite : PS01186
|
|
4)
|
chain |
G |
residue |
91-113 |
type |
prosite |
sequence |
CIKMRLRCNGDNDCGDFSDEDDC
|
description |
LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C
|
source |
prosite : PS01209
|
|
5)
|
chain |
G |
residue |
293-309 |
type |
TRANSMEM |
sequence |
VLTTTFVDDIKALPTTY
|
description |
Beta stranded => ECO:0000255
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
6)
|
chain |
G |
residue |
314-333 |
type |
TRANSMEM |
sequence |
YFAFLETYGTHYSSSGSLGG
|
description |
Beta stranded => ECO:0000255
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
7)
|
chain |
G |
residue |
244 |
type |
SITE |
sequence |
H
|
description |
Cleavage; by thrombin
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
8)
|
chain |
G |
residue |
27 |
type |
CARBOHYD |
sequence |
W
|
description |
C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
9)
|
chain |
G |
residue |
30 |
type |
CARBOHYD |
sequence |
W
|
description |
C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
10)
|
chain |
G |
residue |
256 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
11)
|
chain |
G |
residue |
394 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|