eF-site ID 6gxq-AB PDB Code 6gxq Chain A, B click to enlarge Title Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1335 Classification HYDROLASE Compound Phosphodiesterase Source (Q8WQX9_9TRYP) Sequence A:  VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPL DVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRN VPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLIT ALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHH CNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISN VTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRS KNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIK SNRAQWERVLETR B:  VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPL DVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRN VPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLIT ALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHH CNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISN VTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRS KNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIK SNRAQWERVLET Description Functional site 1) chain A residue 710 type sequence D description binding site for residue MG A 1001 source : AC1 2) chain A residue 673 type sequence H description binding site for residue ZN A 1002 source : AC2 3) chain A residue 709 type sequence H description binding site for residue ZN A 1002 source : AC2 4) chain A residue 710 type sequence D description binding site for residue ZN A 1002 source : AC2 5) chain A residue 822 type sequence D description binding site for residue ZN A 1002 source : AC2 6) chain A residue 644 type sequence K description binding site for residue GAI A 1003 source : AC3 7) chain A residue 768 type sequence E description binding site for residue GAI A 1003 source : AC3 8) chain A residue 753 type sequence L description binding site for residue GAI A 1004 source : AC4 9) chain A residue 754 type sequence S description binding site for residue GAI A 1004 source : AC4 10) chain A residue 759 type sequence D description binding site for residue GAI A 1004 source : AC4 11) chain A residue 762 type sequence D description binding site for residue GAI A 1004 source : AC4 12) chain A residue 769 type sequence R description binding site for residue GAI A 1004 source : AC4 13) chain A residue 915 type sequence L description binding site for residue GAI A 1004 source : AC4 14) chain A residue 785 type sequence M description binding site for residue FFZ A 1005 source : AC5 15) chain A residue 822 type sequence D description binding site for residue FFZ A 1005 source : AC5 16) chain A residue 825 type sequence N description binding site for residue FFZ A 1005 source : AC5 17) chain A residue 873 type sequence G description binding site for residue FFZ A 1005 source : AC5 18) chain A residue 874 type sequence Q description binding site for residue FFZ A 1005 source : AC5 19) chain A residue 877 type sequence F description binding site for residue FFZ A 1005 source : AC5 20) chain A residue 692 type sequence E description binding site for residue GAI A 1006 source : AC6 21) chain A residue 613 type sequence D description binding site for residue GOL A 1007 source : AC7 22) chain A residue 829 type sequence P description binding site for residue GOL A 1007 source : AC7 23) chain A residue 830 type sequence F description binding site for residue GOL A 1007 source : AC7 24) chain A residue 831 type sequence D description binding site for residue GOL A 1007 source : AC7 25) chain A residue 832 type sequence I description binding site for residue GOL A 1007 source : AC7 26) chain B residue 849 type sequence D description binding site for residue GOL A 1007 source : AC7 27) chain B residue 864 type sequence R description binding site for residue GOL A 1007 source : AC7 28) chain B residue 686 type sequence Y description binding site for residue GAI B 1001 source : AC8 29) chain B residue 691 type sequence Y description binding site for residue GAI B 1001 source : AC8 30) chain B residue 710 type sequence D description binding site for residue MG B 1002 source : AC9 31) chain B residue 673 type sequence H description binding site for residue ZN B 1003 source : AD1 32) chain B residue 709 type sequence H description binding site for residue ZN B 1003 source : AD1 33) chain B residue 710 type sequence D description binding site for residue ZN B 1003 source : AD1 34) chain B residue 822 type sequence D description binding site for residue ZN B 1003 source : AD1 35) chain B residue 688 type sequence G description binding site for residue GOL B 1004 source : AD2 36) chain B residue 689 type sequence N description binding site for residue GOL B 1004 source : AD2 37) chain B residue 693 type sequence K description binding site for residue GOL B 1004 source : AD2 38) chain B residue 894 type sequence L description binding site for residue GOL B 1004 source : AD2 39) chain B residue 896 type sequence G description binding site for residue GOL B 1004 source : AD2 40) chain B residue 691 type sequence Y description binding site for residue GOL B 1006 source : AD3 41) chain B residue 694 type sequence L description binding site for residue GOL B 1006 source : AD3 42) chain B residue 695 type sequence T description binding site for residue GOL B 1006 source : AD3 43) chain A residue 709-720 type prosite sequence HDLDHMGLNNSF description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF source prosite : PS00126

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