eF-site ID 6gxq-B PDB Code 6gxq Chain B click to enlarge Title Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1335 Classification HYDROLASE Compound Phosphodiesterase Source (Q8WQX9_9TRYP) Sequence B:  VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPL DVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRN VPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLIT ALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHH CNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISN VTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRS KNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIK SNRAQWERVLET Description Functional site 1) chain B residue 849 type sequence D description binding site for residue GOL A 1007 source : AC7 2) chain B residue 864 type sequence R description binding site for residue GOL A 1007 source : AC7 3) chain B residue 686 type sequence Y description binding site for residue GAI B 1001 source : AC8 4) chain B residue 691 type sequence Y description binding site for residue GAI B 1001 source : AC8 5) chain B residue 710 type sequence D description binding site for residue MG B 1002 source : AC9 6) chain B residue 673 type sequence H description binding site for residue ZN B 1003 source : AD1 7) chain B residue 709 type sequence H description binding site for residue ZN B 1003 source : AD1 8) chain B residue 710 type sequence D description binding site for residue ZN B 1003 source : AD1 9) chain B residue 822 type sequence D description binding site for residue ZN B 1003 source : AD1 10) chain B residue 688 type sequence G description binding site for residue GOL B 1004 source : AD2 11) chain B residue 689 type sequence N description binding site for residue GOL B 1004 source : AD2 12) chain B residue 693 type sequence K description binding site for residue GOL B 1004 source : AD2 13) chain B residue 894 type sequence L description binding site for residue GOL B 1004 source : AD2 14) chain B residue 896 type sequence G description binding site for residue GOL B 1004 source : AD2 15) chain B residue 691 type sequence Y description binding site for residue GOL B 1006 source : AD3 16) chain B residue 694 type sequence L description binding site for residue GOL B 1006 source : AD3 17) chain B residue 695 type sequence T description binding site for residue GOL B 1006 source : AD3

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