eF-site ID 6gl9-B PDB Code 6gl9 Chain B click to enlarge Title Crystal structure of JAK3 in complex with Compound 10 (FM475) Classification TRANSFERASE Compound Tyrosine-protein kinase JAK3 Source (JAK3_HUMAN) Sequence B:  DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALV AVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYG PGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQ ICKGMEYLGSRRCVHRALAARNILVESEAHVKIADFGLAK LLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWS FGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLE LLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALG PQLDMLWSGSR Description Functional site 1) chain B residue 882 type sequence F description binding site for residue EDO A 1205 source : AC5 2) chain B residue 962 type sequence H description binding site for residue EDO A 1205 source : AC5 3) chain B residue 828 type sequence L description binding site for residue F3W B 1201 source : AD2 4) chain B residue 853 type sequence A description binding site for residue F3W B 1201 source : AD2 5) chain B residue 903 type sequence E description binding site for residue F3W B 1201 source : AD2 6) chain B residue 904 type sequence Y description binding site for residue F3W B 1201 source : AD2 7) chain B residue 905 type sequence L description binding site for residue F3W B 1201 source : AD2 8) chain B residue 909 type sequence C description binding site for residue F3W B 1201 source : AD2 9) chain B residue 911 type sequence R description binding site for residue F3W B 1201 source : AD2 10) chain B residue 912 type sequence D description binding site for residue F3W B 1201 source : AD2 11) chain B residue 953 type sequence R description binding site for residue F3W B 1201 source : AD2 12) chain B residue 954 type sequence N description binding site for residue F3W B 1201 source : AD2 13) chain B residue 956 type sequence L description binding site for residue F3W B 1201 source : AD2 14) chain B residue 1011 type sequence W description binding site for residue PHU B 1202 source : AD3 15) chain B residue 1030 type sequence P description binding site for residue PHU B 1202 source : AD3 16) chain B residue 1037 type sequence M description binding site for residue PHU B 1202 source : AD3 17) chain B residue 1059 type sequence R description binding site for residue PHU B 1202 source : AD3 18) chain B residue 1060 type sequence L description binding site for residue PHU B 1202 source : AD3 19) chain B residue 1078 type sequence W description binding site for residue PHU B 1202 source : AD3 20) chain B residue 946 type sequence V description binding site for residue GOL B 1203 source : AD4 21) chain B residue 948 type sequence R description binding site for residue GOL B 1203 source : AD4 22) chain B residue 994 type sequence Y description binding site for residue GOL B 1203 source : AD4 23) chain B residue 995 type sequence A description binding site for residue GOL B 1203 source : AD4 24) chain B residue 998 type sequence S description binding site for residue GOL B 1203 source : AD4 25) chain B residue 1004 type sequence F description binding site for residue GOL B 1203 source : AD4 26) chain B residue 1008 type sequence S description binding site for residue GOL B 1203 source : AD4 27) chain B residue 1009 type sequence D description binding site for residue GOL B 1203 source : AD4 28) chain B residue 1012 type sequence S description binding site for residue GOL B 1203 source : AD4 29) chain B residue 840 type sequence R description binding site for residue EDO B 1204 source : AD5 30) chain B residue 847 type sequence N description binding site for residue EDO B 1204 source : AD5 31) chain B residue 984 type sequence R description binding site for residue EDO B 1204 source : AD5 32) chain B residue 834 type sequence G description binding site for residue EDO B 1205 source : AD6 33) chain B residue 855 type sequence K description binding site for residue EDO B 1205 source : AD6 34) chain B residue 846 type sequence D description binding site for residue EDO B 1206 source : AD7 35) chain B residue 847 type sequence N description binding site for residue EDO B 1206 source : AD7 36) chain B residue 863 type sequence D description binding site for residue EDO B 1206 source : AD7 37) chain B residue 867 type sequence D description binding site for residue EDO B 1206 source : AD7 38) chain B residue 870 type sequence R description binding site for residue EDO B 1206 source : AD7 39) chain B residue 878 type sequence L description binding site for residue EDO B 1207 source : AD8 40) chain B residue 879 type sequence H description binding site for residue EDO B 1207 source : AD8 41) chain B residue 885 type sequence K description binding site for residue EDO B 1207 source : AD8 42) chain B residue 886 type sequence Y description binding site for residue EDO B 1207 source : AD8 43) chain B residue 911 type sequence R description binding site for residue EDO B 1208 source : AD9 44) chain B residue 1019 type sequence E description binding site for residue EDO B 1208 source : AD9 45) chain B residue 1024 type sequence C description binding site for residue EDO B 1208 source : AD9 46) chain B residue 1029 type sequence S description binding site for residue EDO B 1208 source : AD9 47) chain B residue 1029 type sequence S description binding site for residue EDO B 1209 source : AE1 48) chain B residue 1031 type sequence S description binding site for residue EDO B 1209 source : AE1 49) chain B residue 1032 type sequence A description binding site for residue EDO B 1209 source : AE1 50) chain B residue 1035 type sequence L description binding site for residue EDO B 1209 source : AE1 51) chain B residue 949 type ACT_SITE sequence A description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 52) chain B residue 828 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 53) chain B residue 855 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 904 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:18250158 source Swiss-Prot : SWS_FT_FI3 55) chain B residue 939 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:18250158 source Swiss-Prot : SWS_FT_FI3 56) chain B residue 980 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15831699 source Swiss-Prot : SWS_FT_FI4 57) chain B residue 981 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15831699 source Swiss-Prot : SWS_FT_FI4

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