eF-site ID 6gl9-A PDB Code 6gl9 Chain A click to enlarge Title Crystal structure of JAK3 in complex with Compound 10 (FM475) Classification TRANSFERASE Compound Tyrosine-protein kinase JAK3 Source (JAK3_HUMAN) Sequence A:  QDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGAL VAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSY GPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSS QICKGMEYLGSRRCVHRALAARNILVESEAHVKIADFGLA KLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVW SFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLL ELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL GPQLDMLWSGSR Description Functional site 1) chain A residue 828 type sequence L description binding site for residue F3W A 1201 source : AC1 2) chain A residue 836 type sequence V description binding site for residue F3W A 1201 source : AC1 3) chain A residue 853 type sequence A description binding site for residue F3W A 1201 source : AC1 4) chain A residue 903 type sequence E description binding site for residue F3W A 1201 source : AC1 5) chain A residue 904 type sequence Y description binding site for residue F3W A 1201 source : AC1 6) chain A residue 905 type sequence L description binding site for residue F3W A 1201 source : AC1 7) chain A residue 909 type sequence C description binding site for residue F3W A 1201 source : AC1 8) chain A residue 911 type sequence R description binding site for residue F3W A 1201 source : AC1 9) chain A residue 912 type sequence D description binding site for residue F3W A 1201 source : AC1 10) chain A residue 953 type sequence R description binding site for residue F3W A 1201 source : AC1 11) chain A residue 956 type sequence L description binding site for residue F3W A 1201 source : AC1 12) chain A residue 1011 type sequence W description binding site for residue PHU A 1202 source : AC2 13) chain A residue 1030 type sequence P description binding site for residue PHU A 1202 source : AC2 14) chain A residue 1059 type sequence R description binding site for residue PHU A 1202 source : AC2 15) chain A residue 1060 type sequence L description binding site for residue PHU A 1202 source : AC2 16) chain A residue 1078 type sequence W description binding site for residue PHU A 1202 source : AC2 17) chain A residue 946 type sequence V description binding site for residue GOL A 1203 source : AC3 18) chain A residue 948 type sequence R description binding site for residue GOL A 1203 source : AC3 19) chain A residue 994 type sequence Y description binding site for residue GOL A 1203 source : AC3 20) chain A residue 995 type sequence A description binding site for residue GOL A 1203 source : AC3 21) chain A residue 998 type sequence S description binding site for residue GOL A 1203 source : AC3 22) chain A residue 1004 type sequence F description binding site for residue GOL A 1203 source : AC3 23) chain A residue 1008 type sequence S description binding site for residue GOL A 1203 source : AC3 24) chain A residue 1009 type sequence D description binding site for residue GOL A 1203 source : AC3 25) chain A residue 1012 type sequence S description binding site for residue GOL A 1203 source : AC3 26) chain A residue 823 type sequence K description binding site for residue EDO A 1204 source : AC4 27) chain A residue 840 type sequence R description binding site for residue EDO A 1204 source : AC4 28) chain A residue 847 type sequence N description binding site for residue EDO A 1204 source : AC4 29) chain A residue 984 type sequence R description binding site for residue EDO A 1204 source : AC4 30) chain A residue 827 type sequence Q description binding site for residue EDO A 1205 source : AC5 31) chain A residue 830 type sequence K description binding site for residue EDO A 1205 source : AC5 32) chain A residue 831 type sequence G description binding site for residue EDO A 1206 source : AC6 33) chain A residue 834 type sequence G description binding site for residue EDO A 1206 source : AC6 34) chain A residue 855 type sequence K description binding site for residue EDO A 1206 source : AC6 35) chain A residue 846 type sequence D description binding site for residue EDO A 1207 source : AC7 36) chain A residue 847 type sequence N description binding site for residue EDO A 1207 source : AC7 37) chain A residue 863 type sequence D description binding site for residue EDO A 1207 source : AC7 38) chain A residue 867 type sequence D description binding site for residue EDO A 1207 source : AC7 39) chain A residue 870 type sequence R description binding site for residue EDO A 1207 source : AC7 40) chain A residue 875 type sequence L description binding site for residue EDO A 1208 source : AC8 41) chain A residue 876 type sequence K description binding site for residue EDO A 1208 source : AC8 42) chain A residue 878 type sequence L description binding site for residue EDO A 1208 source : AC8 43) chain A residue 879 type sequence H description binding site for residue EDO A 1208 source : AC8 44) chain A residue 885 type sequence K description binding site for residue EDO A 1208 source : AC8 45) chain A residue 886 type sequence Y description binding site for residue EDO A 1208 source : AC8 46) chain A residue 911 type sequence R description binding site for residue EDO A 1209 source : AC9 47) chain A residue 915 type sequence Q description binding site for residue EDO A 1209 source : AC9 48) chain A residue 1019 type sequence E description binding site for residue EDO A 1209 source : AC9 49) chain A residue 1024 type sequence C description binding site for residue EDO A 1209 source : AC9 50) chain A residue 1029 type sequence S description binding site for residue EDO A 1209 source : AC9 51) chain A residue 917 type sequence H description binding site for residue EDO A 1210 source : AD1 52) chain A residue 920 type sequence R description binding site for residue EDO A 1210 source : AD1 53) chain A residue 996 type sequence P description binding site for residue EDO A 1210 source : AD1 54) chain A residue 1054 type sequence L description binding site for residue EDO A 1210 source : AD1 55) chain A residue 1055 type sequence E description binding site for residue EDO A 1210 source : AD1 56) chain A residue 1059 type sequence R description binding site for residue EDO A 1210 source : AD1 57) chain A residue 1080 type sequence P description binding site for residue EDO A 1210 source : AD1 58) chain A residue 949 type ACT_SITE sequence A description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 828 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 855 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 904 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:18250158 source Swiss-Prot : SWS_FT_FI3 62) chain A residue 939 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:18250158 source Swiss-Prot : SWS_FT_FI3 63) chain A residue 980 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15831699 source Swiss-Prot : SWS_FT_FI4 64) chain A residue 981 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15831699 source Swiss-Prot : SWS_FT_FI4 65) chain A residue 828-855 type prosite sequence LGKGNFGSVELCRYDPLGDNTGALVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGNFGSVElCrydplgdntgal......VAVK source prosite : PS00107

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