eF-site ID 6gl8-A PDB Code 6gl8 Chain A click to enlarge Title Crystal structure of Bcl-2 in complex with the novel orally active inhibitor S55746 Classification APOPTOSIS Compound Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2 Source (BCL2_HUMAN) Sequence A:  GSYDNREIVMKYIHYKLSQRGYEWDAGADESEVVHKTLRE AGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFR DGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTE YLNRHLHTWIQDNGGWDAFVELYG Description Functional site 1) chain A residue 104 type sequence F description binding site for residue F3Q A 301 source : AC1 2) chain A residue 108 type sequence Y description binding site for residue F3Q A 301 source : AC1 3) chain A residue 111 type sequence D description binding site for residue F3Q A 301 source : AC1 4) chain A residue 112 type sequence F description binding site for residue F3Q A 301 source : AC1 5) chain A residue 118 type sequence Q description binding site for residue F3Q A 301 source : AC1 6) chain A residue 137 type sequence L description binding site for residue F3Q A 301 source : AC1 7) chain A residue 145 type sequence G description binding site for residue F3Q A 301 source : AC1 8) chain A residue 146 type sequence R description binding site for residue F3Q A 301 source : AC1 9) chain A residue 149 type sequence A description binding site for residue F3Q A 301 source : AC1 10) chain A residue 153 type sequence F description binding site for residue F3Q A 301 source : AC1 11) chain A residue 171 type sequence D description binding site for residue F3Q A 301 source : AC1 12) chain A residue 137-155 type prosite sequence LFRDGVNWGRIVAFFEFGG description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG source prosite : PS01080 13) chain A residue 188-199 type prosite sequence WIQDNGGWDAFV description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV source prosite : PS01258 14) chain A residue 93-107 type prosite sequence VHKTLREAGDDFSRR description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhktLReAGDDFSRR source prosite : PS01259 15) chain A residue 10-30 type prosite sequence DNREIVMKYIHYKLSQRGYEW description BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW source prosite : PS01260 16) chain A residue 95 type MOD_RES sequence K description Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:18570871 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 96 type MOD_RES sequence T description Phosphoserine; by MAPK8 and PKC => ECO:0000269|PubMed:18570871 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 113 type MOD_RES sequence A description Phosphoserine; by MAPK8 => ECO:0000269|PubMed:18570871 source Swiss-Prot : SWS_FT_FI3

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