eF-site ID 6gjq-E PDB Code 6gjq Chain E click to enlarge Title human NBD1 of CFTR in complex with nanobody T27 Classification HYDROLASE Compound Cystic fibrosis transmembrane conductance regulator Source (6GJQ) Sequence E:  DINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSRISF CPQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDI SKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHL KKADKILILHEGSSYFYGTFSELQNLQ Description (1)  Cystic fibrosis transmembrane conductance regulator (E.C.3.6.3.49), Nanobody T27 Functional site 1) chain E residue 495 type sequence S description binding site for residue ATP A 701 source : AC1 2) chain E residue 443 type sequence D description binding site for residue ATP E 701 source : AC3 3) chain E residue 460 type sequence T description binding site for residue ATP E 701 source : AC3 4) chain E residue 461 type sequence G description binding site for residue ATP E 701 source : AC3 5) chain E residue 462 type sequence A description binding site for residue ATP E 701 source : AC3 6) chain E residue 463 type sequence G description binding site for residue ATP E 701 source : AC3 7) chain E residue 464 type sequence K description binding site for residue ATP E 701 source : AC3 8) chain E residue 465 type sequence T description binding site for residue ATP E 701 source : AC3 9) chain E residue 466 type sequence S description binding site for residue ATP E 701 source : AC3 10) chain E residue 493 type sequence Q description binding site for residue ATP E 701 source : AC3 11) chain E residue 549 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI5 12) chain E residue 524 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:22119790 source Swiss-Prot : SWS_FT_FI6 13) chain E residue 458 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT source Swiss-Prot : SWS_FT_FI3 14) chain E residue 493 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS source Swiss-Prot : SWS_FT_FI4

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