eF-site ID 6gjq-C PDB Code 6gjq Chain C click to enlarge Title human NBD1 of CFTR in complex with nanobody T27 Classification HYDROLASE Compound Cystic fibrosis transmembrane conductance regulator Source (6GJQ) Sequence C:  DINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSRISF CPQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDI SKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHL KKADKILILHEGSSYFYGTFSELQNL Description (1)  Cystic fibrosis transmembrane conductance regulator (E.C.3.6.3.49), Nanobody T27 Functional site 1) chain C residue 460 type sequence T description binding site for residue ATP C 701 source : AC2 2) chain C residue 461 type sequence G description binding site for residue ATP C 701 source : AC2 3) chain C residue 462 type sequence A description binding site for residue ATP C 701 source : AC2 4) chain C residue 463 type sequence G description binding site for residue ATP C 701 source : AC2 5) chain C residue 464 type sequence K description binding site for residue ATP C 701 source : AC2 6) chain C residue 465 type sequence T description binding site for residue ATP C 701 source : AC2 7) chain C residue 466 type sequence S description binding site for residue ATP C 701 source : AC2 8) chain C residue 493 type sequence Q description binding site for residue ATP C 701 source : AC2 9) chain C residue 494 type sequence F description binding site for residue ATP G 701 source : AC4 10) chain C residue 495 type sequence S description binding site for residue ATP G 701 source : AC4 11) chain C residue 496 type sequence W description binding site for residue ATP G 701 source : AC4 12) chain C residue 458 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT source Swiss-Prot : SWS_FT_FI3 13) chain C residue 549 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI5 14) chain C residue 524 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:22119790 source Swiss-Prot : SWS_FT_FI6 15) chain C residue 493 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS source Swiss-Prot : SWS_FT_FI4

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