eF-site ID 6gjq-A PDB Code 6gjq Chain A click to enlarge Title human NBD1 of CFTR in complex with nanobody T27 Classification HYDROLASE Compound Cystic fibrosis transmembrane conductance regulator Source (6GJQ) Sequence A:  DINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSRISF CPQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDI SKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHL KKADKILILHEGSSYFYGTFSELQNLQ Description (1)  Cystic fibrosis transmembrane conductance regulator (E.C.3.6.3.49), Nanobody T27 Functional site 1) chain A residue 459 type sequence S description binding site for residue ATP A 701 source : AC1 2) chain A residue 460 type sequence T description binding site for residue ATP A 701 source : AC1 3) chain A residue 461 type sequence G description binding site for residue ATP A 701 source : AC1 4) chain A residue 462 type sequence A description binding site for residue ATP A 701 source : AC1 5) chain A residue 463 type sequence G description binding site for residue ATP A 701 source : AC1 6) chain A residue 464 type sequence K description binding site for residue ATP A 701 source : AC1 7) chain A residue 465 type sequence T description binding site for residue ATP A 701 source : AC1 8) chain A residue 466 type sequence S description binding site for residue ATP A 701 source : AC1 9) chain A residue 493 type sequence Q description binding site for residue ATP A 701 source : AC1 10) chain A residue 494 type sequence F description binding site for residue ATP E 701 source : AC3 11) chain A residue 495 type sequence S description binding site for residue ATP E 701 source : AC3 12) chain A residue 548-562 type prosite sequence LSGGQRARISLARAV description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV source prosite : PS00211 13) chain A residue 549 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI5 14) chain A residue 524 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:22119790 source Swiss-Prot : SWS_FT_FI6 15) chain A residue 458 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT source Swiss-Prot : SWS_FT_FI3 16) chain A residue 493 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS source Swiss-Prot : SWS_FT_FI4

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